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Epigenetic variation across generations: mechanisms and consequences of DNA methylation in Arabidopsis

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If you have a question about this talk, please contact Helen Scott.

The heritable basis of complex traits has long been assumed to depend on the transmission of DNA sequence alleles from parents to offspring. This view is however challenged by the observation that changes in chromatin states can affect gene expression and can be inherited through multiple sexual generations independently of any DNA sequence change . This so-called epigenetic inheritance of chromatin states is best documented in plants and often involves DNA cytosine methylation and small RNAs. Yet, we still know very little about what causes epigenetic variation or how stable and prevalent it is. Here I will illustrate how epigenetic recombinant inbred lines (epiRILs), in which variation in DNA sequence is minimal compared to that in DNA methylation, can be used to assess the stability and phenotypic impact of epigenetic variants genome-wide and in an unbiased manner.

http://www.biologie.ens.fr/a2e/spip.php?article13

This talk is part of the Plant Sciences Departmental Seminars series.

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