Induction, persistence and function of microbiota-specific CD4 T cell memory

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• Jakob Zimmermann, Department for Biomedical Research, University of Berne
• Thursday 10 July 2025, 16:00-17:00
• Lecture Theatre, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus.

If you have a question about this talk, please contact Ruth Paton.

This Cambridge Immunology Network Seminar will take place on Thursday 10 July 2025, starting at 4:00-5:00pm

Speaker: Jakob Zimmermann, Department for Biomedical Research, University of Berne, Germany

Title: “Induction, persistence and function of microbiota-specific CD4 T cell memory”

Abstract: The intestinal microbiota contains a vast array of antigens, which throughout life stimulate mucosal T cell responses. To demonstrate how intermittent exposures to an intestinal symbiont drive antigen-specific CD4 T cell resident memory, we have genetically engineered a mutant strain of Lactobacillus reuteri that reversibly colonizes the gut of germ-free mice. We have combined this system that uncouples microbial exposure from permanent colonization with detection of antigen-specific T cells by custom adoptive transfer and peptide:MHC tools to address the induction, persistence, and function of microbiota-directed CD4 T cell responses. Our findings reveal that benign symbionts elicit long-lived, antigen-independent, tissue-resident CD4 T cells with significant implications for our understanding of host–microbial mutualism in the intestine.

Host: Noe Rodriguez Rodriguez, MRC Laboratory of Molecular Biology

Refreshments will be available following the seminar.

This talk is part of the Cambridge Immunology Network Seminar Series series.

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• Cambridge Immunology Network Seminar Series
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