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University of Cambridge > Talks.cam > Cambridge Immunology Network Seminar Series > Induction, persistence and function of microbiota-specific CD4 T cell memory
![]() Induction, persistence and function of microbiota-specific CD4 T cell memoryAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact Ruth Paton. This Cambridge Immunology Network Seminar will take place on Thursday 10 July 2025, starting at 4:00-5:00pm Speaker: Jakob Zimmermann, Department for Biomedical Research, University of Berne, Germany Title: “Induction, persistence and function of microbiota-specific CD4 T cell memory” Abstract: The intestinal microbiota contains a vast array of antigens, which throughout life stimulate mucosal T cell responses. To demonstrate how intermittent exposures to an intestinal symbiont drive antigen-specific CD4 T cell resident memory, we have genetically engineered a mutant strain of Lactobacillus reuteri that reversibly colonizes the gut of germ-free mice. We have combined this system that uncouples microbial exposure from permanent colonization with detection of antigen-specific T cells by custom adoptive transfer and peptide:MHC tools to address the induction, persistence, and function of microbiota-directed CD4 T cell responses. Our findings reveal that benign symbionts elicit long-lived, antigen-independent, tissue-resident CD4 T cells with significant implications for our understanding of host–microbial mutualism in the intestine. Host: Noe Rodriguez Rodriguez, MRC Laboratory of Molecular Biology Refreshments will be available following the seminar. This talk is part of the Cambridge Immunology Network Seminar Series series. This talk is included in these lists:
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