The (in)fidelity of human mitochondrial gene expression

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• Professor Brendan Battersby, University of Helsinki, Finland
• Tuesday 14 November 2023, 15:00-16:00
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY.

If you have a question about this talk, please contact Lisa Arnold.

Human mitochondria possess one of the most simplified genomes in cellular life. Despite the genome simplicity, the regulatory mechanisms of mitochondrial gene expression remain significant outstanding biological questions. In my group, we investigate the quality control of mitochondrial gene expression, focusing on post-transcriptional and co-translational processes, and how disruptions to these molecular functions manifest into human pathologies. My goal is to understand how these mechanisms are then integrated with organelle membrane dynamics and function across cell types. Our current studies have identified underlying sources of RNA errors in mitochondrial gene expression and the associated ribosome quality control machinery to resolve these aberrations, and how disruptions to these processes manifest across diverse cell types and in animal models of mitochondrial dysfunction. Understanding cell-specific responses to mitochondrial protein synthesis defects will be a key to elucidate the molecular pathogenesis of human mitochondrial disorders.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• CamBridgeSens
• Cambridge talks
• Life Science Interface Seminars
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY
• MRC Mitochondrial Biology Unit Seminars
• Trust & Technology Initiative - interesting events

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