Curbing mitochondrial dysfunction in neurodegeneration: lessons from neurogenetics

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• Dr Derek Narendra | National Institute of Neurological Disorders and Stroke
• Tuesday 25 April 2023, 15:00-16:00
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY.

If you have a question about this talk, please contact Hannah Burns.

Among the causes of neurodegeneration are damaged mitochondria that accumulate with age, particularly in post-mitotic neurons and myocytes. Our group studies monogenic disorders to uncover mitochondrial stress responses that curb mitochondrial damage in neurodegeneration. Our focus includes PINK1 and Parkin, which form a stress-induced mitophagy pathway that targets damaged mitochondria for degradation. Mutations in these genes are the most common recessive forms of Parkinson’s disease, linking mitophagy to neurodegeneration. We are additionally focused on dominant mutations in the paralogs CHCHD2 and CHCHD10 , which cause Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and myopathy. In addition to enabling precision therapies for these neurogenetic disorders, our work is uncovering fundamental mitochondrial stress responses to mitochondrial damage.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• CamBridgeSens
• Cambridge talks
• Life Science Interface Seminars
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY
• MRC Mitochondrial Biology Unit Seminars
• Trust & Technology Initiative - interesting events

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