Biological energy transduction in action - deciphering the molecular mechanism of the remarkable Complex I

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• Professor Ville Kaila | Stockholm University
• Wednesday 01 November 2023, 15:00-16:00
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY.

If you have a question about this talk, please contact Lisa Arnold.

Complex I is a gigantic membrane-bound enzyme that transduces redox energy into a proton motive force across a biological membrane, powering cellular respiration. Despite major advances in recent years, its energy transduction principle remains unsolved and a major challenge. In this talk, I describe our integrative biophysical, computational, and structural approach to derive a molecular understanding of the long-range proton-pumping principles within the Complex I superfamily. Our findings reveal how the substrate reduction triggers conformational and hydration changes, how the protonation signal propagates across the membrane domain of the complex, and how engineering the elementary building blocks allows us to identify key mechanistic principles and probe effects underlying disease-related mutations. We suggest that Complex I employs electric field effects to control both catalysis and ion-transport, with striking physical similarities to other enzymes.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• CamBridgeSens
• Cambridge talks
• Life Science Interface Seminars
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY
• MRC Mitochondrial Biology Unit Seminars
• Trust & Technology Initiative - interesting events

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