Immunity activation and execution in plants: a biochemical perspective

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• Professor Jane Parker, Max Planck Institute, Germany
• Thursday 18 May 2023, 12:15-13:45
• Online / Plant Sciences LLT for Department members only.

If you have a question about this talk, please contact Jake Harris.

For innate immunity, seed plant species have evolved large families of variable receptors to detect pathogen molecules and trigger disease resistance. Intracellular nucleotide-binding/leucine-rich-repeat (NLR) receptors are major determinants of resistance against host-adapted pathogens. Recent advances have been made in determining biochemical processes underlying NLR activation by different pathogen molecules and how pathogen-specific recognition events then signal to resistance and cell death execution machineries. My group has been studying a large NLR receptor sub-class in dicot plants called TIR -NLRs (TNLs) which have Toll-Interleukin1-receptor (TIR) enzymatic signalling domains. I’ll describe our current understanding of TIR domain catalytic functions, when embedded in NLRs but also as TIR -only (non-NLR) proteins, in generating nucleotide-based second messengers for immunity. I’ll also consider emerging evidence of TIR catalytic versatility in producing nucleotide-based stimulators and suppressors of host immune responses across kingdoms.

This talk is part of the Plant Sciences Departmental Seminars series.

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