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Engineering insights into the strange world of cancer

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Bio: Dr. Shiladitya Sengupta is an associate professor of medicine at Harvard Medical School and leads the center for engineered therapeutics at the Mass General-Brigham Hospital. His laboratory use tools from nanotechnology and bioengineering to explore biological phenomenon at unique scales and to design new therapeutics. For example, he developed the first layer-by-layer nanoparticle that allows targeting different components of a tumor on a temporal scale (Nature). Recently, his lab discovered a new mechanism of tumor immune evasion, where the cancer cells harvest immune cell mitochondria through nanoscale tentacles (Nature Nanotechnology). He holds over 50 pending/granted patents, and many of his inventions/research have led to start-ups, which have raised over $300M in R&D funding. Over 100 students and postdoctoral fellows have trained in his laboratory, have won multiple best paper awards and fellowships, and have gone on to successful careers in academia and in the biotech industry. He has received the TR35 Top 35 Global Innovators award from MIT Technology Review magazine, the Era of Hope scholar award, and the Scholar and Innovator award (with Erkki Ruoslahti and Roger Tsien) from US Department of Defense, etc. He completed his undergraduate education at the All India Institute of Medical Sciences, New Delhi, his PhD in Pharmacology as a Nehru and Chevening scholar from Trinity College, Cambridge University, and his fellowship in biological engineering at Massachusetts Institute of Technology, before joining Harvard as faculty.

This talk is part of the Department of Pharmacology Seminar Series series.

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