University of Cambridge > > Babraham Seminar > The B cell receptor and beyond: specialized functions of the BCR in the intestine

The B cell receptor and beyond: specialized functions of the BCR in the intestine

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This talk will take place online via Zoom & Kings Hedges Room

B lymphocytes are central to maintaining balanced enteric responses through production of immunoglobulins (Igs). A large fraction of Igs are produced in germinal center (GC) responses, which form upon immunization or infection in the majority of secondary lymphoid organs, but are constitutively present in gut-associated lymphoid tissue. However, gut-associated GC responses are poorly understood in terms of their ontogeny and antigenic drivers. Using a multicolor fate-mapping approach to visualize GC clonal expansions with a confetti fluorescent allele, we observed single-color GCs in the steady state intestine, suggestive of a strong selection event. By coupling fate-mapping gnotobiotics and Ig sequencing, we showed affinity-driven selection occurring in response to members of the microbiome. We observed that GCs persist even in the absence of microbiota, although their isotype distribution and clonal composition are altered. We identified several prominent public Ig clonotypes in intestinal GCs, whose presence were tuned by microbial diversity.

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