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CATEGORIES:Babraham Seminar
SUMMARY:The B cell receptor and beyond: specialized functi
 ons of the BCR in the intestine - Dr Carla Nowosad
 \; NYU Grossman School of Medicine
DTSTART;TZID=Europe/London:20220831T133000
DTEND;TZID=Europe/London:20220831T143000
UID:TALK176471AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/176471
DESCRIPTION:B lymphocytes are central to maintaining balanced 
 enteric responses through production of immunoglob
 ulins (Igs). A large fraction of Igs are produced 
 in germinal center (GC) responses\, which form upo
 n immunization or infection in the majority of sec
 ondary lymphoid organs\, but are constitutively pr
 esent in gut-associated lymphoid tissue. However\,
  gut-associated GC responses are poorly understood
  in terms of their ontogeny and antigenic drivers.
  Using a multicolor fate-mapping approach to visua
 lize GC clonal expansions with a confetti fluoresc
 ent allele\, we observed single-color GCs in the s
 teady state intestine\, suggestive of a strong sel
 ection event. By coupling fate-mapping gnotobiotic
 s and Ig sequencing\, we showed affinity-driven se
 lection occurring in response to members of the mi
 crobiome. We observed that GCs persist even in the
  absence of microbiota\, although their isotype di
 stribution and clonal composition are altered. We 
 identified several prominent public Ig clonotypes 
 in intestinal GCs\, whose presence were tuned by m
 icrobial diversity.\n\nClick here to join live - h
 ttps://us06web.zoom.us/j/87391153485
LOCATION:Online via zoom &amp\; Kings Hedges Room 
CONTACT:Bobbie Claxton
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