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Spatial heterogeneity of microglia in CNS disease

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Microglia are the tissue resident macrophages of the CNS with typical macrophage properties such as innate immune functions and phagocytic activity. They also possess specific CNS -tailored functions such as synaptic pruning and neuronal support. Microglia express a specific transcriptional profile reflective of their CNS macrophage function. In recent years, several studies have elucidated the changes that occur in microglia in the context of development and CNS disease. With the emergence of single cell sequencing to deep phenotype individual cells, novel findings regarding the role of microglia in human CNS development, homeostasis, and disease will be presented.

This talk is part of the Microglia webinar series series.

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