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Effect of nutrients on microglial function

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Microglia are the brain macrophages, eliciting multifaceted functions to maintain brain homeostasis across lifetime and in all pathophysiological conditions. A new line of research suggests that metabolic plasticity plays a crucial role in regulating microglial function. Hence, the nature of nutrients reaching the brain to feed microglia could control its immunosurveillance ability to maintain homeostasis within the brain. While, brain energy metabolism and substrate availability vary under physiology and disease states, how these variations influence microglial function and eventually affect neuronal control of behavior and physiology is relatively unknown. In this talk, I will detail part of our work on the mechanisms regulating microglial metabolism and the consequences on its activity, when the fueling of the brain has changed, during neurodevelopment or under obesity.

This talk is part of the Microglia webinar series series.

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