Using scRNAseq to understand malaria parasite development and evolution

Add to your list(s) Download to your calendar using vCal

• Dr Virginia Howick
• Wednesday 16 February 2022, 16:00-17:00
• Dixon Greaves Room, Department of Pathology, Tennis Court Road.

If you have a question about this talk, please contact Anna Protasio.

This is a hybrid talk. You can attend in person - no booking required - or via zoom. See abstract for details

Single-cell transcriptomics has revolutionized our understanding of parasite populations. Using this technology, we are now able to understand how a unicellular organism coordinates gene expression throughout development and in response to environmental cues. I will discuss my work in the Malaria Cell Atlas project, which profiled single-cell transcriptomes from across the life cycles of diverse malaria parasites. I will demonstrate how we can use these data to assign potential gene function based on modules of co-expression over developmental time and identify how selection may be acting at different places in the life cycle. Focusing on mosquito stage parasites, I will show how conserved and divergent patterns of gene usage between parasite species point to both essential mechanisms in malaria transmission and species-specific adaptations potentially linked to host tropism. Finally, I will discuss how follow up studies have given insight into functional context and have tied observed expression patterns to unique morphological forms.

This talk will be broadcasted via Zoom. Please use this link to gain access.

This talk is part of the Parasitology Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• Dixon Greaves Room, Department of Pathology, Tennis Court Road
• Graduate-Seminars
• Life Sciences
• Life Sciences
• ME Seminar
• Pathology Seminars
• my_list
• other talks

Note that ex-directory lists are not shown.