University of Cambridge > > MRC Mitochondrial Biology Unit Seminars > “How mitochondria control immune T cell killing"

“How mitochondria control immune T cell killing"

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  • UserProfessor Gillian Griffiths | Cambridge Institute for Medical Research World_link
  • ClockWednesday 12 January 2022, 15:00-16:00
  • HouseOnline (Zoom) - details tbc.

If you have a question about this talk, please contact Hannah Burns.

In a functional screen of 454 single gene knockout mice we identified genes with previously unknown roles in the immune system, that impact T cell killing. We have mapped many different steps in the order of events that lead to secretion to allow us to pinpoint when and where mutations disrupt effector function in killer T cells. We have now characterized several of these mutants using a combination of imaging, biochemical, functional and proteomic approaches to identify the molecular mechanisms that allow these novel immune genes to regulate T cell. This presentation will focus on two mutations that revealed an unexpected role for mitochondria in controlling T cell killing and the future studies emerging from these findings.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

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