Statistical analysis and optimality of biological systems

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• Prof Gasper Tkacik
• Thursday 22 April 2021, 15:00-16:00
• Online.

If you have a question about this talk, please contact Sarah Morgan.

Normative theories and statistical inference provide complementary approaches for the study of biological systems. A normative theory postulates that organisms have adapted to efficiently solve essential tasks and proceeds to mathematically work out testable consequences of such optimality; parameters that maximize the hypothesized organismal function can be derived ab initio, without reference to experimental data. In contrast, statistical inference focuses on the efficient utilization of data to learn model parameters, without reference to any a priori notion of biological function. Traditionally, these two approaches were developed independently and applied separately. Here, we unify them in a coherent Bayesian framework that embeds a normative theory into a family of maximum-entropy “optimization priors.” This family defines a smooth interpolation between a data-rich inference regime and a data-limited prediction regime. I will illustrate how this framework can productively guide our thinking on several neuroscience and non-neuroscience examples.

This talk is part of the Making connections- brains and other complex systems series.

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