University of Cambridge > > Plant Sciences Departmental Seminars > Defying Mendel’s laws: epigenetic insights from the sulfurea paramutation in Solanum Lycopersicum

Defying Mendel’s laws: epigenetic insights from the sulfurea paramutation in Solanum Lycopersicum

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  • UserClaudia Dos Santos Martinho, Baulcombe group World_link
  • ClockThursday 05 November 2020, 13:00-14:00
  • HouseOnline.

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Gene silencing events can distort meiotically heritable epigenetic responses by altering gene expression without involving changes in DNA sequences. Paramutation is such a gene silencing process, found across kingdoms, that involves the trans silencing of an active (paramutable) allele caused by a silent (paramutagenic) allele. The silent-state of the paramutable allele is heritable and this allele can become paramutagenic in subsequent generations thereby altering Mendelian patterns of inheritance. The establishment and maintenance of paramutation has been mostly explained by models invoking small RNA (sRNA) mediated silencing to explain the transfer of epigenetic marks between homologue chromosomes.

This talk will address a particular case of paramutation, the sulfurea (sulf) allele, which is a silent and paramutagenic epigenetic variant of a tomato (Solanum lycopersicum cv Lukullus) gene involved in chlorophyll synthesis. Using genetic analysis, sRNA sequencing, chromatin conformation capture (HiC/4C) in chlorotic leave tissues, I will discuss the molecular mechanism underlying the maintenance of paramutation.

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This talk is part of the Plant Sciences Departmental Seminars series.

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