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University of Cambridge > Talks.cam > Seminars at the Department of Biochemistry > Mycobacterial structural biology and prospects for drug development in academia
Mycobacterial structural biology and prospects for drug development in academiaAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact mad58. This talk has been canceled/deleted During my talk, I will summarize the current status of our knowledge on the structural proteome of mycobacteria, especially that of Mycobacterium tuberculosis [1]. Then I will give examples of our own past and most recent research related to three topics: • Biosynthesis of specific lipids of the mycobacterial cell envelope [2-9] • Phosphopantetheinyl transferases as drug targets of M. tuberculosis and other human pathogens [10-11] • Chaperone-mediated control of a toxin-antitoxin system from M. tuberculosis [12-14] [1] Pedelacq, J.-D., Nguyen, M.C., Terwilliger, T.C., and Mourey, L. (2020). A Comprehensive Review on Mycobacterium tuberculosis Targets and Drug Development from a Structural Perspective. In Structural Biology in Drug Discovery, J.-P. Renaud, ed. (John Wiley & Sons, Ltd), pp. 545–66. [2-9] Boissier et al. J Biol Chem (2006) 281:4434-45; Vaubourgeix et al. J Biol Chem (2009) 284:19321-30; Pedelacq et al. Nucleic Acids Res (2011) 39:e125; Bergeret et al. J Biol Chem (2012) 287:33675-90; Gavalda et al. Chem Biol (2014) 21:1660-9; Chollet et al. J Struct Biol (2015) 190:328-37; Guillet et al. (2016) J Biol Chem 291:7973-89; Faille et al. (2017) J Mol Biol 429:1554-69. [10-11] Leblanc et al. PLoS Pathog (2012) 8:e1003097; Rottier et al. J Struct Biol 183:320-8. [12-14] Bordes et al. Nat Commun (2016) 7:13339; Sala et al. Proc Natl Acad Sci U S A 114 :12584-9 (2017); Guillet et al. (2019) Nat Commun 10:782. This talk is part of the Seminars at the Department of Biochemistry series. This talk is included in these lists:This talk is not included in any other list Note that ex-directory lists are not shown. |
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