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Mycobacterial structural biology and prospects for drug development in academia

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During my talk, I will summarize the current status of our knowledge on the structural proteome of mycobacteria, especially that of Mycobacterium tuberculosis [1]. Then I will give examples of our own past and most recent research related to three topics:

• Biosynthesis of specific lipids of the mycobacterial cell envelope [2-9]

• Phosphopantetheinyl transferases as drug targets of M. tuberculosis and other human pathogens [10-11]

• Chaperone-mediated control of a toxin-antitoxin system from M. tuberculosis [12-14]

[1] Pedelacq, J.-D., Nguyen, M.C., Terwilliger, T.C., and Mourey, L. (2020). A Comprehensive Review on Mycobacterium tuberculosis Targets and Drug Development from a Structural Perspective. In Structural Biology in Drug Discovery, J.-P. Renaud, ed. (John Wiley & Sons, Ltd), pp. 545–66.

[2-9] Boissier et al. J Biol Chem (2006) 281:4434-45; Vaubourgeix et al. J Biol Chem (2009) 284:19321-30; Pedelacq et al. Nucleic Acids Res (2011) 39:e125; Bergeret et al. J Biol Chem (2012) 287:33675-90; Gavalda et al. Chem Biol (2014) 21:1660-9; Chollet et al. J Struct Biol (2015) 190:328-37; Guillet et al. (2016) J Biol Chem 291:7973-89; Faille et al. (2017) J Mol Biol 429:1554-69. [10-11] Leblanc et al. PLoS Pathog (2012) 8:e1003097; Rottier et al. J Struct Biol 183:320-8. [12-14] Bordes et al. Nat Commun (2016) 7:13339; Sala et al. Proc Natl Acad Sci U S A 114 :12584-9 (2017); Guillet et al. (2019) Nat Commun 10:782.

This talk is part of the Seminars at the Department of Biochemistry series.

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