BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Mycobacterial structural biology and prospects for drug developmen
 t in academia - Dr Lionel Mourey 
DTSTART:20200505T120000Z
DTEND:20200505T130000Z
UID:TALK134848@talks.cam.ac.uk
CONTACT:38852
DESCRIPTION:During my talk\, I will summarize the current status of our kn
 owledge on the structural proteome of mycobacteria\, especially that of My
 cobacterium tuberculosis [1]. Then I will give examples of our own past an
 d most recent research related to three topics:\n\n•	Biosynthesis of spe
 cific lipids of the      mycobacterial cell envelope [2-9]   \n\n•	Phosp
 hopantetheinyl transferases as drug targets of M. tuberculosis and other h
 uman pathogens [10-11]\n\n•	Chaperone-mediated control of a toxin-antito
 xin system from M. tuberculosis [12-14] \n\n[1] Pedelacq\, J.-D.\, Nguyen\
 , M.C.\, Terwilliger\, T.C.\, and Mourey\, L. (2020). A Comprehensive Revi
 ew on Mycobacterium tuberculosis Targets and Drug Development from a Struc
 tural Perspective. In Structural Biology in Drug Discovery\, J.-P. Renaud\
 , ed. (John Wiley & Sons\, Ltd)\, pp. 545–66.\n\n[2-9] Boissier et al. J
  Biol Chem (2006) 281:4434-45\; Vaubourgeix et al. J Biol Chem (2009) 284:
 19321-30\; Pedelacq et al. Nucleic Acids Res (2011) 39:e125\; Bergeret et 
 al. J Biol Chem (2012) 287:33675-90\; Gavalda et al. Chem Biol (2014) 21:1
 660-9\; Chollet et al. J Struct Biol (2015) 190:328-37\; Guillet et al. (2
 016) J Biol Chem 291:7973-89\; Faille et al. (2017) J Mol Biol 429:1554-69
 . \n[10-11] Leblanc et al. PLoS Pathog (2012) 8:e1003097\; Rottier et al. 
 J Struct Biol 183:320-8.\n[12-14] Bordes et al. Nat Commun (2016) 7:13339\
 ; Sala et al. Proc Natl Acad Sci U S A 114:12584-9 (2017)\; Guillet et al.
  (2019) Nat Commun 10:782.\n\n\n\n
LOCATION:Department of Biochemistry\, Sanger Building\, Thomas Lecture The
 atre
END:VEVENT
END:VCALENDAR