Mitochondrial dynamics in muscle physiopathology

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• Professor Marco Sandri | University of Padova, Italy
• Wednesday 03 July 2019, 15:00-16:00
• Sackler Lecture Theatre (Level 7) The Keith Peters Building, Cambridge Biomedical Campus.

If you have a question about this talk, please contact Hannah Burns.

Mitochondrial quality control is essential in highly structured cells such as neurons and muscles. In skeletal muscle the mitochondrial shaping machinery and mitophagy are altered in different physiopathological conditions that are characterized by muscle loss and weakness. The abnormal mitochondria signal to the nucleus to induce several signaling pathways that control proteostasis, inflammatory response and senescence. Importantly, the shape of the mitochondrial network more than mitochondrial function is an important factor for the activation of specific pathways that control peculiar phenotypes. Fusion defect triggers sarcopenia and systemic ageing while fission impairment causes myopathy. Here, I will present the latest data that connect mitochondrial network to signaling pathways that controls muscle mass.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• CamBridgeSens
• Cambridge talks
• Life Science Interface Seminars
• MRC Mitochondrial Biology Unit Seminars
• Sackler Lecture Theatre (Level 7) The Keith Peters Building, Cambridge Biomedical Campus
• Trust & Technology Initiative - interesting events

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