Comparative glucocorticoid metabolism; lessons from horses, humans and mice

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• Dr Ruth Morgan, University of Edinburgh
• Wednesday 14 November 2018, 16:00-17:00
• Lecture Theatre 2, Department of Veterinary Medicine.

If you have a question about this talk, please contact Fiona Roby.

Activation of the hypothalamic-pituitary-adrenal (HPA) axis and altered tissue glucocorticoid action in obesity, metabolic syndrome and hypertension has been attributed to altered peripheral cortisol metabolism. Our work investigates the role of glucocorticoid metabolism, transport and receptor activation in horses, humans and mice and the impact of glucocorticoid metabolism on health and disease. We have identified novel pathways of cortisol metabolism in the horse associated with disease and have gone on to look at these pathways in humans and in animal models of disease. We focus on predominant cortisol metabolite in horses, 20β-dihydrocortisol which we have shown to be a preferential agonist of the mineralocorticoid receptor and our current work aims to elucidate the role of this metabolism in obesity associated hypertension in different species.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• Departmental Seminar Programme, Department of Veterinary Medicine
• Lecture Theatre 2, Department of Veterinary Medicine
• Vet School Seminars

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