A Mathematical Modelling Framework for a Virtual Solid Tumour: Foundation for an Oncological Digital Twin

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• Mark Chaplain (University of St Andrews)
• Friday 19 September 2025, 14:50-15:10
• Seminar Room 1, Newton Institute.

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OOEW07 - Mathematical Foundations of Oncological Digital Twins

In this talk we will present a mathematical modelling framework for a virtual solid tumour. The framework will be built around a multiscale force-based individual-based model of an avascular multicellular spheroid. We will discuss how this basic framework may be extended to include two critical (macroscale) hallmarks of cancer: tumour-induced angiogenesis and cancer invasion and metastasis. We will then sketch a path to create an oncological digital twin.

This talk is part of the Isaac Newton Institute Seminar Series series.

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