Investigating the role of glycosylation in Toxoplasma gondii protein homeostasis

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• Dr. Giulia Bandini. University of York.
• Wednesday 17 November 2021, 16:00-17:00
• Marjory Stephenson Seminar Room, Hopkins Building, Dept of Biochemistry.

If you have a question about this talk, please contact Anna Protasio.

Due to unforeseen circumstances, this talk will be delivered VIA ZOOM ONLY. See abstract for link.

Protein glycosylation is one of the most abundant and widespread post-translational modifications (PTMs). It is involved in many biological processes including host-pathogen interactions and protein quality control. The study of glycosylation in protozoan parasites is especially valuable. Not only it addresses key aspects of pathogen biology but can also provide insights in the evolution of glycosylation pathways, as these are early divergent eukaryotes. In this talk I will focus on Toxoplasma gondii, an opportunistic pathogen of humans, and the function of glycosylation in both the quality control and kinetics of protein folding and stabilisation. I will highlight what we know and what we don’t know about the glycosylation pathways that can affect protein homeostasis in the parasite and provide the example of TgSPY, a paralog of host O-GlcNAc transferase. TgSPY modifies Toxoplasma nucleocytoplasmic proteins with O-fucose and this modification has implications for protein expression and virulence. Biochemical and functional studies on this glycosyltransferase can advance our understanding of glycosylation in eukaryotic cells while also reporting back on fundamental parasite processes.

This talk will be broadcasted via Zoom. Please use this link to gain access.

This talk is part of the Parasitology Seminars series.

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