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SUMMARY:Investigating the role of glycosylation in Toxoplasma gondii prote
 in homeostasis - Dr. Giulia Bandini. University of York.
DTSTART:20211117T160000Z
DTEND:20211117T170000Z
UID:TALK163696@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:Protein glycosylation is one of the most abundant and widespre
 ad post-translational modifications (PTMs). It is involved in many biologi
 cal processes including host-pathogen interactions and protein quality con
 trol. The study of glycosylation in protozoan parasites is especially valu
 able. Not only it addresses key aspects of pathogen biology but can also p
 rovide insights in the evolution of glycosylation pathways\, as these are 
 early divergent eukaryotes.\nIn this talk I will focus on Toxoplasma gondi
 i\, an opportunistic pathogen of humans\, and the function of glycosylatio
 n in both the quality control and kinetics of protein folding and stabilis
 ation. I will highlight what we know and what we don't know about the glyc
 osylation pathways that can affect protein homeostasis in the parasite and
  provide the example of TgSPY\, a paralog of host O-GlcNAc transferase. Tg
 SPY modifies Toxoplasma nucleocytoplasmic proteins with O-fucose and this 
 modification has implications for protein expression and virulence.  Bioch
 emical and functional studies on this glycosyltransferase can advance our 
 understanding of glycosylation in eukaryotic cells while also reporting ba
 ck on fundamental parasite processes.\n\nThis talk will be broadcasted via
  Zoom. Please use this "link":https://zoom.us/j/95026514738?pwd=aUtoam1zbD
 RYYWU0M1Nob2VPQXNvZz09 to gain access. 
LOCATION:Marjory Stephenson Seminar Room\, Hopkins Building\, Dept of Bioc
 hemistry
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