Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 28 March 2018, 10:15-11:15

Using Computational Structure Biology to Study Diseases that cause Major Health Concerns in Brazil

User Dr Pedro Torres.

Wednesday 21 March 2018, 10:30-11:30

Not Too Big - Not Too Small: Fragment Antibody Drug Candidates as Alternatives to Antibodies for Solid Tumours

User Dr Gokhan Yahioglu (Director of Medicinal Chemistry, Antikor Biopharma Ltd).

Monday 19 March 2018, 10:15-11:15

Mycobacterium Tuberculosis Physiology: The Intricate Interplay between Drug Tolerance and Drug Resistance

User Caroline Pule (Faculty of Medicine, Stellenbosch University, South Africa).

Wednesday 07 March 2018, 10:15-11:15

Shortening Tuberculosis Chemotherapies: Elucidating the Molecular genetic programs of persistence of M. tuberculosis

User Professor W. Jacobs, Howard Hughes Medical Institute, NY.

Monday 26 February 2018, 10:15-11:15

Human 2-oxoacid-dependent Oxygenases

User Dr M. S. Islam (Department of Biochemistry, University of Cambridge).

Wednesday 24 January 2018, 10:30-11:15

The simple reason that M. avium subspecies paratuberculosis has been missed as a major human pathogen is that, unknowingly, it's been treated since 1942

User Dr Robert Greenstein (VA Medical Center, Bronx, NY).

Wednesday 13 December 2017, 10:15-11:15

Signalling through interleukin/interferon receptors: outside and inside of the cell

User Dr. Alexander Wlodawer (Chief, Macromolecular Crystallography Laboratory, NCI-Frederick).

Wednesday 11 October 2017, 10:15-11:15

Linking Structural Biology and Clinical Genomics: Purine Nucleotidase in Relapsed Leukemia

User Dr. Aleš Hnízda (Academy of Sciences of the Czech Republic, Prague; From 1st June: Department of Biochemistry, University of Cambridge).

Wednesday 31 May 2017, 10:15-11:15

Revolutionary Cryo-EM: the Potential Power to Visualize High Resolution Dynamic Structures

User Dr Kai Zhang (LMB).

Wednesday 24 May 2017, 10:15-11:15

Rebuilding the HDX-MS Method to Support Integrative Methods in Structural Biology

User Dr David Schriemer (University of Calgary, Alberta).

Wednesday 10 May 2017, 10:15-11:15

High-Throughput Fragment-Based Drug Discovery at Diamond Synchrotron: Robots can do much of the work to screen in FBDD!

User Prof Frank von Delft (Diamond Light Source / Structural Genomics Consortium - Oxford).

Monday 03 April 2017, 10:15-11:15

COSMIC Catalogue of Cancer Mutations and the 3D Proteome

User Simon Forbes & Harry Jubb (Sanger Institute, Wellcome Genome Campus).

House Biochemistry Lecture Theatre, Sanger Building.

Wednesday 29 March 2017, 10:15-11:15

Dynamic interactions and fuzzy structures in protein complexes and higher-order assemblies

User Dr Monika Fuxreiter.

Thursday 23 March 2017, 10:15-11:15

Using Integrative Methods in Structural Biology to Understand Protein Structure

User Dr Daniel Saltzberg (University of California, San Francisco).

Wednesday 08 March 2017, 10:15-11:15

Computational study of mutations in proteins

User Professor Douglas Pires (Centro de Pesquisas René Rachou, FIOCRUZ - Minas Gerais, Brazil).

House Biochemistry Lecture Theatre, Sanger Building.

Wednesday 01 March 2017, 10:15-11:15

Myc and MexR: conformational selection and fuzzy complexes in transcriptional regulation

User Prof Maria Sunnerhagen (Linkoping University, Sweden).

Tuesday 28 February 2017, 14:30-15:30

What's new at PDBe?

User Dr Deepti Gupta and Dr John Berrisford (PDBe).

Wednesday 25 January 2017, 10:15-11:15

Phosphoproteomic strategies reveal global impact of kinase inhibitors on regulatory kinase networks and the phosphoproteome

User Prof David Litchfield (University of Western Ontario).

Wednesday 16 November 2016, 14:30-16:00

A computational framework for optimizing combination drug therapies

User Dr Michael Lyons (Colorado State University).

Wednesday 26 October 2016, 10:15-11:15

Structure and Function of TIFA - A New Player in Immunity and Cancer

User Prof Ming-Daw Tsai (Academia Sinica in Taiwan).

Monday 10 October 2016, 15:00-16:00

Interactive molecular dynamics for improved model building and exploration in structural biology

User Dr Tristan Croll (CIMR, Cambridge).

Wednesday 28 September 2016, 10:15-11:15

Predicting the impact of natural and disease variants on protein function

User Professor Rob Russell (Heidelberg University).

Wednesday 13 July 2016, 10:15-11:15

Targeting Trehalose and Methylglucose Lipopolysaccharide Pathways of M. tuberculosis

User Nupur Verma (Department of Biochemistry, Cambridge).

Wednesday 15 June 2016, 10:15-11:15

TBC

User Dr Owen Davies (Newcastle University).

Wednesday 01 June 2016, 10:15-11:15

Matching density maps of macromolecular assemblies from Cryo-EM and assessment of fitted atomic models

User Dr Agnel Praveen Joseph.

Wednesday 25 May 2016, 10:15-11:15

The 3D structures of genomes in single cells reveal principles of nuclear organization

User Dr Tim Stevens (LMB, Cambridge).

Wednesday 18 May 2016, 10:15-11:15

The E. coli replisome caught in the act by cryo-EM and single molecule microscopy

User Dr Meindert Lamers (LMB).

Wednesday 27 April 2016, 14:00-15:00

Pregnancy outcome prediction using placenta epigenetic data

User Dr Sung Gong (Clinical School of Medicine).

Wednesday 02 March 2016, 10:15-11:15

Protein transport to the endoplasmic reticulum

User Dr Rebecca Voorhees (LMB).

Wednesday 20 January 2016, 10:15-11:15

Computational approaches to investigate protein-nucleic acid and protein-protein interactions

User Dr Sony Malhotra (Department of Biochemistry).

Wednesday 16 December 2015, 10:15-11:15

Mapping of ligand binding site and activation mechanism of APJ receptor

User Prashant Kumar (Department of Biochemistry).

Wednesday 02 December 2015, 10:15-11:15

Dr Paul Brear - Inhibiting CK2α from outside the active site

User Paul Brear - Department of Biochemistry.

Wednesday 25 November 2015, 10:15-11:15

Prof Song Tan - TBC

User Professor Song Tan (Penn State University).

Wednesday 18 November 2015, 10:15-11:15

Fitting atomic structures into EM density maps

User Dr Arun Prasad Pandurangan (Department of Biochemistry).

Wednesday 04 November 2015, 10:15-11:15

Migle Kisonaite - "Structure of Gremlin-1: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism" and Xuelu Wang "Understanding of the Pro-domain in TGF-β Superfamily: Structure and Characterisation of Pro-activin A"

User Xuelu Wang and Migle Kisonaite - Department of Biochemistry.

Wednesday 28 October 2015, 10:15-11:15

ARCIMBOLDO, an ab initio approach to MR phasing

User Isabel Uson (Molecular Biology Institute of Barcelona).

Wednesday 21 October 2015, 10:15-11:15

Atomic resolution cryoEM structure of bacteriophage

User Prof. Wah Chiu, Baylor College of Medicine, Texas.

Wednesday 02 September 2015, 10:15-11:15

Modulating Protein-Protein Interactions

User Dr Jessica Holien - St. Vincent's Institute for Medical Research.

Wednesday 26 August 2015, 15:00-16:00

Title to be confirmed

User Dr Dijana Matak-Vinkovic, Dept. Chemistry, Cambridge.

Wednesday 24 June 2015, 10:15-11:15

Structural Biology and Transmembrane Signalling: Understanding a 'Double-edged' Receptor, DCC

User Jia-Huai Wang (Harvard).

Wednesday 17 June 2015, 10:15-11:15

Impact of rapid whole-genome sequencing on diagnostic and public health microbiology

User Dr Claudio U. Köser, Dept. Medicine and Wellcome Trust Genome Campus.

Wednesday 03 June 2015, 10:15-11:15

Structural Mechanisms in Protein Kinase Regulation

User Professor John Kuriyan, Berkeley.

Wednesday 20 May 2015, 10:15-11:15

Predicting drug-target binding kinetics through enhanced sampling simulations

User Professor Francesco Gervasio, Dept. Chemistry, University College London.

Wednesday 13 May 2015, 10:15-11:15

Biodiversity and Drug Discovery

User Professor Glaucius Oliva, Universidade de São Paulo.

Thursday 07 May 2015, 16:30-17:30

Recent advances in high resolution cryo-EM structure determination

User Xiaochen Bai, LMB-MRC.

House Biochemistry Seminar Room, Sanger Building, Tennis Court Road.

Wednesday 29 April 2015, 10:15-11:30

Dr Meindert Lamers - Title to be confirmed

User Dr Meindert Lamers - LMB.

Wednesday 25 February 2015, 10:15-11:15

Dr Isaac Westwood - Title to be Confirmed

User Dr Isaac Westwood - Institute of Cancer Research.

Wednesday 18 February 2015, 10:15-11:30

Dr Christian Ottmann, Title to be confirmed

User Dr. Christian Ottmann Associate Professor, (UHD) Molecular Cell and Structural Biology, Chemical Biology, Dpt. of Biomedical Engineering and Institute for Complex Molecular Systems, Technische Universiteit, EINDHOVEN.

Wednesday 04 February 2015, 10:15-11:15

Investigating the human proteasome by cryo-EM - an emerging tool for structural based drug design

User Dr Paula de Fonseca - MRC LMB.

Wednesday 28 January 2015, 10:15-11:30

Dr Takashi Ochi and Dr Qian Wu

User Dr Takashi Ochi, Department of Biochemistry, University of Cambridge, u. k.

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Wednesday 21 January 2015, 10:15-11:30

Tools for refinement against low resolution X-ray data and fit to EM reconstructions

User Dr Garib Murshudov, LMB, MRC.

Wednesday 03 December 2014, 11:00-12:00

Identification and characterization of interaction sites with MD simulations of mixed solvents – Application to non-standard targets

User Professor Xavier Barril, ICREA Research Professor at Barcelona University, Spain.

Wednesday 12 November 2014, 10:15-11:15

(1) An introduction to Gene Synthesis - capabilities and uses. (2) An introduction to precise genome editing with TAL effectors and CRISPR

User Nikolai Netuschil and Nahush Karnataki. ThermoFisher Scientific.

Wednesday 29 October 2014, 10:15-11:15

Support Science and Diamond Light Source

User Carina Lobley, DLS.

House Seminar Room 2, Hopkins Building.

Wednesday 15 October 2014, 10:15-11:15

Professor Randy Read - title to be comfirmed

User Professor Randy Read, CIMR, Cambridge.

Wednesday 08 October 2014, 10:15-11:15

Structures and mechanisms of macromolecular complexes involved in transcription and DNA repair

User Professor Xiaodong Zhang Imperial College London Department of Life Sciences.

Wednesday 11 June 2014, 10:15-11:15

Crystal structure of the Drosophila Toll-Spätzle complex reveals neurotrophin-like binding specificity

User Monique Gangloff, Biochemistry.

Wednesday 28 May 2014, 10:15-11:15

How insulin binds to the insulin receptor: structural biology and protein engineering

User Dr Michael Weiss, School of Medicine Cleveland, USA.

Wednesday 09 April 2014, 10:15-11:15

The Structure of the Large Subunit of the Yeast Mitochondrial Ribosome

User Dr Alan Brown.

Wednesday 02 April 2014, 10:15-11:15

Coot's EM Model-fitting Tools

User Dr Paul Emsley, MRC-LMB, Cambridge, U.K..

Wednesday 26 March 2014, 10:15-11:15

Small Angle X-ray Scattering: sample preparation, data collection, and data analysis.

User Dr Meindert Lamers, MRC-LMB, Cambridge, U.K.

Wednesday 26 February 2014, 10:15-11:15

Cyclofluidic: Quick hit-to-lead optimization using an integrated microfluidic approach

User Dr Ronald Dorenbos, Business Development Director Europe Cyclofluidic Ltd..

Wednesday 05 February 2014, 10:15-11:15

Title to be confirmed

User Paula de Fonseca - LMB.

Tuesday 28 January 2014, 10:15-11:30

Using evolutionary sequence variation to make inferences about protein structure and function

User Lucy J. Colwell, Department of Chemistry, University of Cambridge.

Wednesday 22 January 2014, 10:15-11:15

Protein-Protein Interaction Networks and Diseases

User Franca Fraternali, Randall Division of Cell and Molecular Biophysics, King's College London, UK .

Wednesday 27 November 2013, 10:15-11:15

Analysis of allosteric communication and functional local motions using a Structural Alphabe

User Alessandro Pandini,Randall Division of Cell and Molecular Biophysics,King's College London, UK .

Wednesday 27 November 2013, 10:15-11:15

Chirality as a crossroad of chemistry and biology

User Professor Reiko KURODA, Tokyo University of Science (Japan).

Wednesday 13 November 2013, 10:15-11:15

Title to be confirmed

User Shaoxia Chen, MRC-LMB, cambridge.

Wednesday 06 November 2013, 10:15-11:15

Evolution & dynamics of protein complexes

User Sarah Teichmann, Wellcome Trust Sanger Institute.

Wednesday 30 October 2013, 10:15-11:15

Crystallisation and structure of respiratory complex I, a giant molecular proton pump

User Leonid Sazanov, MRC Mitochondrial Biology Unit, Wellcome Trust / MRC Building, cambridge.

Wednesday 23 October 2013, 10:15-11:15

Probing dynamic conformational changes in lipid signalling using hydrogen deuterium exchangemass spectrometry

User Dr John Burke, LMB, Cambridge U.K.

House Biochemistry Lecture Theatre, Sanger Building.

Wednesday 27 March 2013, 10:15-11:15

Open Source Drug Discovery: Developing a Systems Level Translational Platform for Neglected Diseases

User Prof. Samir K. Brahmachari, Founder Director, Institute of Genomics and Integrative Biology, Director General, Council of Scientific & Industrial Research, Delhi, India.

Friday 22 March 2013, 13:00-14:00

PHASER workshop

User Airlie McCoy, CIMR, University of Cambridge.

Wednesday 27 February 2013, 10:15-11:15

OPPF-UK: a national resource centre for protein production.

User Dr Louise Bird, OPPF, UK.

Wednesday 13 February 2013, 10:15-11:15

AnchorQuery: Interactive and efficient discovery tool of small molecule protein-protein interaction antagonists

User Carlos Carmachio.

Wednesday 21 November 2012, 10:15-11:15

Identifying hot-spots and designing small molecule inhibitors at protein-protein interfaces: taking advantage of bound water networks

User Dr David J. Huggins, Department of Oncology Hutchison/MRC Research Centre.

Wednesday 07 November 2012, 10:15-11:15

The importance of thermostability and its application to the structure determination of GPCRs

User Dr Chris Tate, LMB.

Wednesday 24 October 2012, 10:15-11:15

X-ray diffraction data reduction: space group determination, scaling and intensity statistics

User Dr Phil Evans, FRS, LMB.

Wednesday 10 October 2012, 10:15-11:15

Title to be confirmed

User Helen Saibil.

Wednesday 13 June 2012, 10:15-11:15

Structural studies of chromosome segregation

User Martin Singleton.

Wednesday 02 May 2012, 10:15-11:15

SAXS studies on biological molecules at Diamond Light Source

User Inoue Katsuaki, DLS, UK.

Wednesday 25 April 2012, 10:15-11:15

Domain swapping in proteins

User Dr Sowdhamini, National Centre for Biological Sciences (TIFR) UAS-GKVK Campus Bellary Road Bangalore 560 065 INDIA.

Wednesday 21 December 2011, 10:15-11:15

To be confirmed

User Dr Bissan Al-Lazikani, Computational Biology and Chemogenomics Institute of Cancer Research, U.K.

Wednesday 07 December 2011, 10:15-11:15

Low Resolution Crystallography

User Dr Dima Chirgadze, Biochemistry Department, University of Cambridge.

Wednesday 30 November 2011, 10:15-11:15

Making candy for signal transduction research - Adventures in Willy Wonka land

User Prof Morten Grötli, Department of Chemistry, University of Gothenburg.

Thursday 24 November 2011, 11:00-12:00

Low resolution refinement tools in the program REFMAC

User Dr Garib N Murshudov, LMB, MRC, Cambridge, U.K.

Wednesday 23 November 2011, 10:15-11:15

Fuzzy complexes: ambiguity in protein-protein and protein-DNA interactions

User Professor Monika Fuxreiter Institute of Enzymology, Budapest, HUNGARY and LMB, MRC, Cambridge, UK.

Wednesday 16 November 2011, 10:15-11:15

Structural complexomics of eukaryotic gene expression.

User Dr Imre Berger, EMBL, Grenoble, France.

Wednesday 27 July 2011, 10:15-11:00

Receptor-based Drug Discovery

User Dr Jiye Shi, UCB Celltech.

House Room 2, Stem Cell Research Centre.

Wednesday 13 July 2011, 10:15-11:00

Probing protein-ligand recognition mechanisms with isothermal titration calorimetry

User Dr Mark Williams. Birkbeck College.

Wednesday 06 July 2011, 11:00-12:00

Crystal dehydration: Experimental design with a home source and at the synchroton

User Dr Juan Sanchez Weatherby: Diamond, UK.

Wednesday 22 June 2011, 10:15-11:00

Designing Bioactive Molecules and Mode-of-Action Analyses - The Benefits of Learning From the Past.

User Dr Andreas Bender, Unilever Centre, Cambridge.

Wednesday 15 June 2011, 10:15-11:00

Drug Protein Interaction Databases

User Adrian Schreyer, Alicia Higueruelo, Will Pitt.

Wednesday 26 January 2011, 10:15-11:00

The Ghosts of PDBe Past, Present and Yet to Come

User Dr Gerard Kleywegt, PDB Europe, EBI, Hinxton.

Wednesday 12 January 2011, 10:15-11:00

i-SITE: An energetic approach to predict ligand-binding site on protein surface

User Dr Mizuki Morita, Laboratory of Bioinformatics, National Institute of Biomedical Innovation (NIBIO), Japan.

Monday 10 January 2011, 11:30-12:00

The rational design of small-molecule Neuropilin-1 antagonists

User Trevor Perrior, Research Director of Domainex.

Wednesday 14 July 2010, 10:15-11:00

Restraints on Protein Models from NMR Chemical Shifts

User Rinaldo Wander Montalvao (Chemistry, Cambridge)..

Wednesday 07 July 2010, 10:35-11:00

Software for fragment linking and growing.

User Nikolay Todorov (Molscape).

Wednesday 07 July 2010, 10:15-11:00

Using Biacore for fragment screening

User Catherine McDonnell, GE Healthcare.

Wednesday 30 June 2010, 10:15-11:00

Off-site Targets: Predicting drug polypharmacology using ligand similarity ensembles.

User Michael Keiser (UCSF).

Wednesday 23 June 2010, 10:15-11:00

Targetting Protein-Protein Interactions: Synergies between NCEs and New Antibodies.

User Dr Alastair Lawson (UCB- Celltech).

Wednesday 16 June 2010, 10:15-11:00

Fragment-based drug discovery using X-ray crystallography.

User Dr Anne Cleasby (Astex).

Wednesday 02 June 2010, 10:15-11:00

Can machines understand the Scientific Literature?

User Professor Peter Murray Rust (Unilever Centre, Chemistry, Cambridge).

Wednesday 19 May 2010, 10:15-11:00

Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY

User Dr Ilona Nudelman, Weizmann Institute.

Monday 10 May 2010, 11:15-12:00

Engineering proteins for fragment screening

User Speaker to be confirmed.

Wednesday 17 March 2010, 10:15-11:00

Surface Plasmon Resonance

User Speaker to be confirmed.

Wednesday 10 March 2010, 10:15-11:00

STING_DB

User Dr Goran Neshi, Laboratorio de Biologia Computacional, Cidade Universitária "Zeferino Vaz" , Campinas, Brazil.

Wednesday 24 February 2010, 10:15-11:00

Drug-protein Databases: ZINC, Credo, CHEMBL

User Will; Adrian.

Wednesday 17 February 2010, 10:15-11:00

Fragments versus traditional screening . Off-target analysis

User Speaker to be confirmed.

Wednesday 10 February 2010, 10:15-11:00

ITC

User Leo and Marko.

Wednesday 03 February 2010, 10:15-11:00

X-ray single soaks or cocktails? Growing versus Linking.

User Round table (Tom and May to lead), Dave Huggins.

Wednesday 27 January 2010, 10:15-11:00

Targetting PPI

User Alicia and Narcis Fernandez-Fuentes from the Leeds Institute of Molecular Medine (LIMM).

Wednesday 20 January 2010, 10:15-11:00

Recap of Experimental Fragment-based projects

User May, Marko, Anja, Anna, Michal, Sachin, Marcio, Leo, Noha.

House Lecture theatre, Sanger Building.

Wednesday 13 January 2010, 10:15-11:00

Completely in vitro protein engineering automation

User Prof Homme Hellinga, Duke University.

Monday 16 November 2009, 16:00-17:00

Molecular recognition - from single target to protein complexes

User Dr Agata Kranjc Pietrucci from International School of Advanced Studies, Trieste, Italy.

House Lecture theatre, Sanger Building.

Thursday 15 October 2009, 11:00-12:00

HIV-1 Reverse Transcriptase: Structure, Drug Resistance, and Drug Design

User Professor Eddy Arnold, Rutgers University.

Thursday 11 June 2009, 16:00-17:00

The microseed matrix screening method for protein crystallisation

User Dr May Marsh.

Wednesday 03 June 2009, 10:15-11:00

Electrochemically-assisted protein crystallisation: Applications to biosensors

User Professor Abel Moreno.

Wednesday 01 April 2009, 10:15-11:00

Public domain medicinal chemistry data at the EBI and the use in drug discovery

User Dr John Overington, Chemogenomics and ChEMBL Databases, European Bioinformatics Institute (EMBL-EBI).

Wednesday 11 March 2009, 10:00-11:00

The influence of electric and magnetic fields to increase the crystal quality of proteins

User Professor Abel Moreno.

Wednesday 04 March 2009, 10:15-11:00

The role of impurities in protein crystallisation: advantages and disadvantages

User Professor Abel Moreno.

Wednesday 11 February 2009, 10:15-11:00

Protein Crystal Growth in Gels and Capillary Tubes

User Professor Abel Moreno.

Wednesday 04 February 2009, 10:15-11:00

Conventional and non-conventional methods of protein crystal growth

User Professor Abel Moreno.

House Unilever Lecture Theatre, Department of Chemistry.

Wednesday 28 January 2009, 10:15-11:00

Recent adventures in protein folding and design

User Professor Lynne Regan, Yale University.

Monday 15 December 2008, 11:00-12:00

Leaving drinks for Sheena

User Dr Sheena D'Arcy.

House Panton Arms pub, Panton Street.

Friday 05 December 2008, 17:30-23:59

SPR - theory and practise

User Dr Joe Maman.

House Meeting Room A.

Thursday 04 December 2008, 13:00-14:00

Biocore

User Speaker to be confirmed.

House Lecture Theatre, Department of Biochemistry, Hopkins Building (old building).

Wednesday 03 December 2008, 16:00-17:00

Expression systems for protein complexes

User Dr Imre Berger, EMBL, Heidelberg.

House Lecture Theatre, Department of Biochemistry, Hopkins Building (old building).

Wednesday 19 November 2008, 16:00-17:00

Pathway-based analysis of genome-wide siRNA screens

User Dr. Miguel Camargo, Merck, Boston USA.

Wednesday 12 November 2008, 10:15-11:00

Party for Richard and Timo

User All welcome!.

House Seminar Room, Sanger Building ?.

Friday 24 October 2008, 15:00-16:00

Fragment-based Screening and It's Role in Ontario Cancer Institute

User Prof Nickolay Chirgadze, Department of Pharmacology and Toxicology, University of Toronto.

Sunday 12 October 2008, 11:15-12:00

Molecular Puzzles: Learning About Function and Mechanism of Enzymes From their Structures

User Dr. Alex Wlodawer, Macromolecular Crystallography Laboratory, National Cancer Institute Frederick.

Friday 10 October 2008, 13:00-14:00

Convergence of Molecular Epidemiology, Functional Biology and Host-pathogen Interactions: Zeroing on Potential Drug Targets for M. TUBERCULOSIS

User Professor Seyed E. Hasnain, Vice-Chancellor University of Hyderabad.

Wednesday 08 October 2008, 11:00-12:00

test

User Speaker to be confirmed.

Thursday 14 August 2008, 10:30-11:30

Neurotrophic factors in Drosophila

User Dr Alicia Hidalgo, University of Birmingham.

Friday 18 July 2008, 10:30-11:30

Small hydrogen-bonded motifs in proteins and their significance for amyloid formation

User James Milner-White, University of Glasgow.

House Meeting Room B, Sanger Building.

Thursday 26 June 2008, 11:30-12:30

Structural chemistry in the pharmaceutical industry: view from a returned exile

User Dr Nic Harmer, University of Exeter.

Monday 12 May 2008, 13:00-14:00

DNA site-specific recombination: Architecture of a recombinase

User Professor Marshall Stark University of Glasgow.

House Biochemistry Lecture Theatre, Sanger Building.

Wednesday 09 April 2008, 12:00-13:00

Mechanisms of Transmembrane Transport: towards structures of membrane protein drug targets

User Professor Robert Stroud, University of California, San Francisco.

Monday 07 April 2008, 13:00-14:00

Toll like receptors - Investigating innate immunity and infection

User Dr Kathy Triantafilou, Infection and immunity Group, University of Sussex.

Friday 28 March 2008, 10:30-11:30

High intrinsic binding specificity mediates the interactions of a yeast SH3 domain

User Dr. Elliott Stollar, Program in Molecular Structure and Function, Hospital for Sick Children, Toronto.

Friday 14 March 2008, 12:00-13:00

Expriences in Structure-based Discovery

User Prof Rod Hubbard, Vernalis and University of York.

Monday 03 March 2008, 09:00-10:00

Fragment based drug discovery - from crystal to clinic

User Dr David Rees, Astex Therapeutics.

Monday 03 December 2007, 09:00-10:00

Paradoxical Features of Nicotinic Receptor

User Professor Stuart Edelstein, University of Geneva.

Wednesday 14 November 2007, 12:00-13:00

New protein purification columns and media from GE Healthcare

User Penny Hamlyn, GE Healthcare.

House Biochemistry Lecture Theatre, Sanger Building.

Thursday 08 November 2007, 11:00-12:00

UCB Approaches to Drug Discovery, A Focus on 2 Cambridge projects

User Dr Will Pitt, UCB Celltech.

Monday 05 November 2007, 09:00-10:00

Structural basis of fatty acid synthesis catalyzed by giant multienzyme complexes

User Dr Nenad Ban, Professor of Structural Molecular Biology, ETH Zurich, Swiss Federal Institute of Technology.