Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

tRNA Modifications and Decoding Errors

Professor Eric Westhof (Institut de Biologie Moléculaire et Cellulaire du CNRS, Université de Strasbourg).

Jean Thomas Lecture Theatre, Sanger Biochemistry Building.

Wednesday 20 February 2019, 16:00-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

A Saposin-lipoprotein nanoparticle system for membrane proteins

Dr Jens Frauenfeld (CEO Salipro Biotech, Sweden).

Jean Thomas Lecture Theatre, Sanger Biochemistry Building.

Monday 03 December 2018, 15:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Capturing the 3D Folds of Whole Mammalian Genomes in Single Cells

Dr Tim Stevens (Cell Biology Division, LMB).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 28 November 2018, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein:protein recognition in the Ubiquitin Proteasome-degradation System (UPS) and Membrane Surface Complexes from the Ras-family

Dr Andrew Byrd (Head of Macromolecular NMR, National Cancer Institute, Maryland).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 31 October 2018, 16:00-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural studies of a DNA unwinding machine

Dr Laura Spagnolo (University of Glasgow).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 20 June 2018, 10:15-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Architecture of PIKK Kinases and their molecular mechanisms of regulation

Dr Taiana De Oliveira (Astra Zeneca).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 20 June 2018, 10:15-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein and Peptide Mass Spectrometry Analysis

Dr Anja Andrejeva (Cambridge Centre for Proteomics).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 06 June 2018, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Solution-based angular measurements of protein structure and conformational change by second-harmonic generation (SHG)

Dr Joshua Salafsky (Founder and CSO, Biodesy Inc, San Francisco).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 23 May 2018, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fragment based inhibition of CK2α

Dr Paul Brear (Hyvonen Group).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 16 May 2018, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Correlative tweezers fluorescence microscopy: one step towards real-time single-molecule biology

Dr Joanna Andrecka (Lumicks).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 09 May 2018, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Substrate reduction enabled by structural biology as therapy for metabolic disorders

Dr Gustavo Arruda Bezerra (Structural Genomics Consortium – University of Oxford).

Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 25 April 2018, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Toward the Reconstitution of the Maturation of Okazaki Fragments Multiprotein Complex in Human at the Single Molecule Level

Dr Luay Joudeh (Pellegrini Group).

Biochemistry Seminar Room, Sanger Building.

Wednesday 28 March 2018, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Using Computational Structure Biology to Study Diseases that cause Major Health Concerns in Brazil

Dr Pedro Torres.

Biochemistry Seminar Room, Sanger Building.

Wednesday 21 March 2018, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Not Too Big - Not Too Small: Fragment Antibody Drug Candidates as Alternatives to Antibodies for Solid Tumours

Dr Gokhan Yahioglu (Director of Medicinal Chemistry, Antikor Biopharma Ltd).

Biochemistry Seminar Room, Sanger Building.

Monday 19 March 2018, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Mycobacterium Tuberculosis Physiology: The Intricate Interplay between Drug Tolerance and Drug Resistance

Caroline Pule (Faculty of Medicine, Stellenbosch University, South Africa).

Biochemistry Seminar Room, Sanger Building.

Wednesday 07 March 2018, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Shortening Tuberculosis Chemotherapies: Elucidating the Molecular genetic programs of persistence of M. tuberculosis

Professor W. Jacobs, Howard Hughes Medical Institute, NY.

Biochemistry Seminar Room, Sanger Building.

Monday 26 February 2018, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Human 2-oxoacid-dependent Oxygenases

Dr M. S. Islam (Department of Biochemistry, University of Cambridge).

Biochemistry Seminar Room, Sanger Building.

Wednesday 24 January 2018, 10:30-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The simple reason that M. avium subspecies paratuberculosis has been missed as a major human pathogen is that, unknowingly, it's been treated since 1942

Dr Robert Greenstein (VA Medical Center, Bronx, NY).

Biochemistry Seminar Room, Sanger Building.

Wednesday 13 December 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Signalling through interleukin/interferon receptors: outside and inside of the cell

Dr. Alexander Wlodawer (Chief, Macromolecular Crystallography Laboratory, NCI-Frederick).

Biochemistry Seminar Room, Sanger Building.

Wednesday 11 October 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Linking Structural Biology and Clinical Genomics: Purine Nucleotidase in Relapsed Leukemia

Dr. Aleš Hnízda (Academy of Sciences of the Czech Republic, Prague; From 1st June: Department of Biochemistry, University of Cambridge).

Biochemistry Seminar Room, Sanger Building.

Wednesday 31 May 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Revolutionary Cryo-EM: the Potential Power to Visualize High Resolution Dynamic Structures

Dr Kai Zhang (LMB).

Biochemistry Seminar Room, Sanger Building.

Wednesday 24 May 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Rebuilding the HDX-MS Method to Support Integrative Methods in Structural Biology

Dr David Schriemer (University of Calgary, Alberta).

Biochemistry Seminar Room, Sanger Building.

Wednesday 10 May 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

High-Throughput Fragment-Based Drug Discovery at Diamond Synchrotron: Robots can do much of the work to screen in FBDD!

Prof Frank von Delft (Diamond Light Source / Structural Genomics Consortium - Oxford).

Biochemistry Seminar Room, Sanger Building.

Monday 03 April 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

COSMIC Catalogue of Cancer Mutations and the 3D Proteome

Simon Forbes & Harry Jubb (Sanger Institute, Wellcome Genome Campus).

Biochemistry Seminar Room, Sanger Building.

Wednesday 29 March 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dynamic interactions and fuzzy structures in protein complexes and higher-order assemblies

Dr Monika Fuxreiter.

Biochemistry Lecture Theatre, Sanger Building.

Thursday 23 March 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Using Integrative Methods in Structural Biology to Understand Protein Structure

Dr Daniel Saltzberg (University of California, San Francisco).

Biochemistry Seminar Room, Sanger Building.

Wednesday 08 March 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Computational study of mutations in proteins

Professor Douglas Pires (Centro de Pesquisas René Rachou, FIOCRUZ - Minas Gerais, Brazil).

Biochemistry Seminar Room, Sanger Building.

Wednesday 01 March 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Myc and MexR: conformational selection and fuzzy complexes in transcriptional regulation

Prof Maria Sunnerhagen (Linkoping University, Sweden).

Biochemistry Lecture Theatre, Sanger Building.

Tuesday 28 February 2017, 14:30-15:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

What's new at PDBe?

Dr Deepti Gupta and Dr John Berrisford (PDBe).

Biochemistry Seminar Room, Sanger Building.

Wednesday 25 January 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Phosphoproteomic strategies reveal global impact of kinase inhibitors on regulatory kinase networks and the phosphoproteome

Prof David Litchfield (University of Western Ontario).

Biochemistry Seminar Room, Sanger Building.

Wednesday 16 November 2016, 14:30-16:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

A computational framework for optimizing combination drug therapies

Dr Michael Lyons (Colorado State University).

Biochemistry Seminar Room, Sanger Building.

Wednesday 26 October 2016, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structure and Function of TIFA - A New Player in Immunity and Cancer

Prof Ming-Daw Tsai (Academia Sinica in Taiwan).

Biochemistry Seminar Room, Sanger Building.

Monday 10 October 2016, 15:00-16:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Interactive molecular dynamics for improved model building and exploration in structural biology

Dr Tristan Croll (CIMR, Cambridge).

Biochemistry Seminar Room, Sanger Building.

Wednesday 28 September 2016, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Predicting the impact of natural and disease variants on protein function

Professor Rob Russell (Heidelberg University).

Biochemistry Seminar Room, Sanger Building.

Wednesday 13 July 2016, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Targeting Trehalose and Methylglucose Lipopolysaccharide Pathways of M. tuberculosis

Nupur Verma (Department of Biochemistry, Cambridge).

Biochemistry Seminar Room, Sanger Building.

Wednesday 15 June 2016, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

TBC

Dr Owen Davies (Newcastle University).

Biochemistry Seminar Room, Sanger Building.

Wednesday 01 June 2016, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Matching density maps of macromolecular assemblies from Cryo-EM and assessment of fitted atomic models

Dr Agnel Praveen Joseph.

Biochemistry Seminar Room, Sanger Building.

Wednesday 25 May 2016, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The 3D structures of genomes in single cells reveal principles of nuclear organization

Dr Tim Stevens (LMB, Cambridge).

Biochemistry Seminar Room, Sanger Building.

Wednesday 18 May 2016, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The E. coli replisome caught in the act by cryo-EM and single molecule microscopy

Dr Meindert Lamers (LMB).

Biochemistry Seminar Room, Sanger Building.

Wednesday 27 April 2016, 14:00-15:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Pregnancy outcome prediction using placenta epigenetic data

Dr Sung Gong (Clinical School of Medicine).

Biochemistry Seminar Room, Sanger Building.

Wednesday 02 March 2016, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein transport to the endoplasmic reticulum

Dr Rebecca Voorhees (LMB).

Biochemistry Seminar Room, Sanger Building.

Wednesday 20 January 2016, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Computational approaches to investigate protein-nucleic acid and protein-protein interactions

Dr Sony Malhotra (Department of Biochemistry).

Biochemistry Seminar Room, Sanger Building.

Wednesday 16 December 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Mapping of ligand binding site and activation mechanism of APJ receptor

Prashant Kumar (Department of Biochemistry).

Biochemistry Seminar Room, Sanger Building.

Wednesday 02 December 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Paul Brear - Inhibiting CK2α from outside the active site

Paul Brear - Department of Biochemistry.

Biochemistry Seminar Room, Sanger Building.

Wednesday 25 November 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Prof Song Tan - TBC

Professor Song Tan (Penn State University).

Biochemistry Seminar Room, Sanger Building.

Wednesday 18 November 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fitting atomic structures into EM density maps

Dr Arun Prasad Pandurangan (Department of Biochemistry).

Biochemistry Seminar Room, Sanger Building.

Wednesday 04 November 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Migle Kisonaite - "Structure of Gremlin-1: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism" and Xuelu Wang "Understanding of the Pro-domain in TGF-β Superfamily: Structure and Characterisation of Pro-activin A"

Xuelu Wang and Migle Kisonaite - Department of Biochemistry.

Biochemistry Seminar Room, Sanger Building.

Wednesday 28 October 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

ARCIMBOLDO, an ab initio approach to MR phasing

Isabel Uson (Molecular Biology Institute of Barcelona).

Biochemistry Seminar Room, Sanger Building.

Wednesday 21 October 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Atomic resolution cryoEM structure of bacteriophage

Prof. Wah Chiu, Baylor College of Medicine, Texas.

Biochemistry Seminar Room, Sanger Building.

Wednesday 02 September 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Modulating Protein-Protein Interactions

Dr Jessica Holien - St. Vincent's Institute for Medical Research.

Biochemistry Seminar Room, Sanger Building.

Wednesday 26 August 2015, 15:00-16:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Title to be confirmed

Dr Dijana Matak-Vinkovic, Dept. Chemistry, Cambridge.

Biochemistry Seminar Room, Sanger Building.

Wednesday 24 June 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural Biology and Transmembrane Signalling: Understanding a 'Double-edged' Receptor, DCC

Jia-Huai Wang (Harvard).

Biochemistry Seminar Room, Sanger Building.

Wednesday 17 June 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Impact of rapid whole-genome sequencing on diagnostic and public health microbiology

Dr Claudio U. Köser, Dept. Medicine and Wellcome Trust Genome Campus.

Biochemistry Seminar Room, Sanger Building.

Wednesday 03 June 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural Mechanisms in Protein Kinase Regulation

Professor John Kuriyan, Berkeley.

Biochemistry Seminar Room, Sanger Building.

Wednesday 20 May 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Predicting drug-target binding kinetics through enhanced sampling simulations

Professor Francesco Gervasio, Dept. Chemistry, University College London.

Biochemistry Seminar Room, Sanger Building.

Wednesday 13 May 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Biodiversity and Drug Discovery

Professor Glaucius Oliva, Universidade de São Paulo.

Biochemistry Seminar Room, Sanger Building.

Thursday 07 May 2015, 16:30-17:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Recent advances in high resolution cryo-EM structure determination

Xiaochen Bai, LMB-MRC.

Biochemistry Seminar Room, Sanger Building.

Wednesday 29 April 2015, 10:15-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Meindert Lamers - Title to be confirmed

Dr Meindert Lamers - LMB.

Biochemistry Seminar Room, Sanger Building, Tennis Court Road.

Wednesday 25 February 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Isaac Westwood - Title to be Confirmed

Dr Isaac Westwood - Institute of Cancer Research.

Biochemistry Seminar Room, Sanger Building.

Wednesday 18 February 2015, 10:15-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Christian Ottmann, Title to be confirmed

Dr. Christian Ottmann Associate Professor, (UHD) Molecular Cell and Structural Biology, Chemical Biology, Dpt. of Biomedical Engineering and Institute for Complex Molecular Systems, Technische Universiteit, EINDHOVEN.

Biochemistry Seminar Room, Sanger Building.

Wednesday 04 February 2015, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Investigating the human proteasome by cryo-EM - an emerging tool for structural based drug design

Dr Paula de Fonseca - MRC LMB.

Biochemistry Seminar Room, Sanger Building.

Wednesday 28 January 2015, 10:15-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Takashi Ochi and Dr Qian Wu

Dr Takashi Ochi, Department of Biochemistry, University of Cambridge, u. k.

Biochemistry Seminar Room, Sanger Building.

Wednesday 21 January 2015, 10:15-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Tools for refinement against low resolution X-ray data and fit to EM reconstructions

Dr Garib Murshudov, LMB, MRC.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Wednesday 03 December 2014, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Identification and characterization of interaction sites with MD simulations of mixed solvents – Application to non-standard targets

Professor Xavier Barril, ICREA Research Professor at Barcelona University, Spain.

Biochemistry Seminar Room, Sanger Building.

Wednesday 12 November 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

(1) An introduction to Gene Synthesis - capabilities and uses. (2) An introduction to precise genome editing with TAL effectors and CRISPR

Nikolai Netuschil and Nahush Karnataki. ThermoFisher Scientific.

Biochemistry Seminar Room, Sanger Building.

Wednesday 29 October 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Support Science and Diamond Light Source

Carina Lobley, DLS.

Biochemistry Seminar Room, Sanger Building.

Wednesday 15 October 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Professor Randy Read - title to be comfirmed

Professor Randy Read, CIMR, Cambridge.

Seminar Room 2, Hopkins Building.

Wednesday 08 October 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structures and mechanisms of macromolecular complexes involved in transcription and DNA repair

Professor Xiaodong Zhang Imperial College London Department of Life Sciences.

Biochemistry Seminar Room, Sanger Building.

Wednesday 11 June 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Crystal structure of the Drosophila Toll-Spätzle complex reveals neurotrophin-like binding specificity

Monique Gangloff, Biochemistry.

Biochemistry Seminar Room, Sanger Building.

Wednesday 28 May 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

How insulin binds to the insulin receptor: structural biology and protein engineering

Dr Michael Weiss, School of Medicine Cleveland, USA.

Biochemistry Seminar Room, Sanger Building.

Wednesday 09 April 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The Structure of the Large Subunit of the Yeast Mitochondrial Ribosome

Dr Alan Brown.

Biochemistry Seminar Room, Sanger Building.

Wednesday 02 April 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Coot's EM Model-fitting Tools

Dr Paul Emsley, MRC-LMB, Cambridge, U.K..

Biochemistry Seminar Room, Sanger Building.

Wednesday 26 March 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Small Angle X-ray Scattering: sample preparation, data collection, and data analysis.

Dr Meindert Lamers, MRC-LMB, Cambridge, U.K.

Biochemistry Seminar Room, Sanger Building.

Wednesday 26 February 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Cyclofluidic: Quick hit-to-lead optimization using an integrated microfluidic approach

Dr Ronald Dorenbos, Business Development Director Europe Cyclofluidic Ltd..

Biochemistry Seminar Room, Sanger Building.

Wednesday 05 February 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Title to be confirmed

Paula de Fonseca - LMB.

Biochemistry Seminar Room, Sanger Building.

Tuesday 28 January 2014, 10:15-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Using evolutionary sequence variation to make inferences about protein structure and function

Lucy J. Colwell, Department of Chemistry, University of Cambridge.

Biochemistry Seminar Room, Sanger Building.

Wednesday 22 January 2014, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein-Protein Interaction Networks and Diseases

Franca Fraternali, Randall Division of Cell and Molecular Biophysics, King's College London, UK .

Biochemistry Seminar Room, Sanger Building.

Wednesday 27 November 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Analysis of allosteric communication and functional local motions using a Structural Alphabe

Alessandro Pandini,Randall Division of Cell and Molecular Biophysics,King's College London, UK .

Biochemistry Seminar Room, Sanger Building.

Wednesday 27 November 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Chirality as a crossroad of chemistry and biology

Professor Reiko KURODA, Tokyo University of Science (Japan).

Biochemistry Seminar Room, Sanger Building.

Wednesday 13 November 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Title to be confirmed

Shaoxia Chen, MRC-LMB, cambridge.

Biochemistry Seminar Room, Sanger Building.

Wednesday 06 November 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Evolution & dynamics of protein complexes

Sarah Teichmann, Wellcome Trust Sanger Institute.

Biochemistry Seminar Room, Sanger Building.

Wednesday 30 October 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Crystallisation and structure of respiratory complex I, a giant molecular proton pump

Leonid Sazanov, MRC Mitochondrial Biology Unit, Wellcome Trust / MRC Building, cambridge.

Biochemistry Seminar Room, Sanger Building.

Wednesday 23 October 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Probing dynamic conformational changes in lipid signalling using hydrogen deuterium exchangemass spectrometry

Dr John Burke, LMB, Cambridge U.K.

Perham's seminar room.

Wednesday 27 March 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Open Source Drug Discovery:  Developing a Systems Level Translational Platform for Neglected Diseases

Prof. Samir K. Brahmachari, Founder Director, Institute of Genomics and Integrative Biology,  Director General, Council of Scientific & Industrial Research,  Delhi, India.

Biochemistry Lecture Theatre, Sanger Building.

Friday 22 March 2013, 13:00-14:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

PHASER workshop

Airlie McCoy, CIMR, University of Cambridge.

Perham's seminar room.

Wednesday 27 February 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

OPPF-UK: a national resource centre for protein production.

Dr Louise Bird, OPPF, UK.

Perham's seminar room.

Wednesday 13 February 2013, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

AnchorQuery: Interactive and efficient discovery tool of small molecule protein-protein interaction antagonists

Carlos Carmachio.

Perham's seminar room.

Wednesday 21 November 2012, 10:15-11:15

Identifying hot-spots and designing small molecule inhibitors at protein-protein interfaces: taking advantage of bound water networks.

Dr David J. Huggins, Department of Oncology Hutchison/MRC Research Centre.

Seminar Room.

Wednesday 07 November 2012, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Identifying hot-spots and designing small molecule inhibitors at protein-protein interfaces: taking advantage of bound water networks

Dr David J. Huggins, Department of Oncology Hutchison/MRC Research Centre.

Perham's seminar room.

Wednesday 07 November 2012, 10:15-11:15

to be confirmed

Chris Tate, MRC-LMB, U.K.

Seminar Room.

Wednesday 24 October 2012, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The importance of thermostability and its application to the structure determination of GPCRs

Dr Chris Tate, LMB.

Perham's seminar room.

Wednesday 24 October 2012, 10:15-11:15

to be confirmed

Dr Phil Evans, FRS, LMB,.

Seminar Room.

Wednesday 10 October 2012, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

X-ray diffraction data reduction: space group determination, scaling and intensity statistics

Dr Phil Evans, FRS, LMB.

Perham's seminar room.

Wednesday 10 October 2012, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Title to be confirmed

Helen Saibil.

Perham's seminar room.

Wednesday 13 June 2012, 10:15-11:15

Structural studies of chromosome segregation

Dr Martin Singleton.

Seminar Room.

Wednesday 02 May 2012, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural studies of chromosome segregation

Martin Singleton.

Perham's seminar room.

Wednesday 02 May 2012, 10:15-11:15

Title to be confirmed

Inoue Katsuaki, DLS, UK.

Seminar Room.

Wednesday 25 April 2012, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

SAXS studies on biological molecules at Diamond Light Source

Inoue Katsuaki, DLS, UK.

Perham's seminar room.

Wednesday 25 April 2012, 10:15-11:15

Automated data processing with autoPROC and the importance of data collection strategy

Andrew Sharff.

Seminar Room.

Wednesday 15 February 2012, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Domain swapping in proteins

Dr Sowdhamini, National Centre for Biological Sciences (TIFR) UAS-GKVK Campus Bellary Road Bangalore 560 065 INDIA.

Perham's seminar room.

Wednesday 21 December 2011, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

To be confirmed

Dr Bissan Al-Lazikani, Computational Biology and Chemogenomics Institute of Cancer Research, U.K.

Perham's seminar room.

Wednesday 07 December 2011, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Low Resolution Crystallography

Dr Dima Chirgadze, Biochemistry Department, University of Cambridge.

Perham's seminar room.

Wednesday 30 November 2011, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Making candy for signal transduction research - Adventures in Willy Wonka land

Prof Morten Grötli, Department of Chemistry, University of Gothenburg.

Perham's seminar room.

Thursday 24 November 2011, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Low resolution refinement tools in the program REFMAC

Dr Garib N Murshudov, LMB, MRC, Cambridge, U.K.

Perham's seminar room.

Wednesday 23 November 2011, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fuzzy complexes: ambiguity in protein-protein and protein-DNA interactions

Professor Monika Fuxreiter Institute of Enzymology, Budapest, HUNGARY and LMB, MRC, Cambridge, UK.

Perham's seminar room.

Wednesday 16 November 2011, 10:15-11:15

Using molecular replacement to exploit multiple crystal forms

professor Randy J. Read.

Seminar Room.

Wednesday 19 October 2011, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural complexomics of eukaryotic gene expression.

Dr Imre Berger, EMBL, Grenoble, France.

Seminar Room, Sanger Building.

Wednesday 27 July 2011, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Receptor-based Drug Discovery

Dr Jiye Shi, UCB Celltech.

Seminar Room, Sanger Building.

Wednesday 13 July 2011, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Probing protein-ligand recognition mechanisms with isothermal titration calorimetry

Dr Mark Williams. Birkbeck College.

Room 2, Stem Cell Research Centre.

Wednesday 06 July 2011, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Crystal dehydration: Experimental design with a home source and at the synchroton

Dr Juan Sanchez Weatherby: Diamond, UK.

Seminar Room, Sanger Building.

Wednesday 22 June 2011, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Designing Bioactive Molecules and Mode-of-Action Analyses - The Benefits of Learning From the Past.

Dr Andreas Bender, Unilever Centre, Cambridge.

Seminar Room, Sanger Building.

Wednesday 15 June 2011, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Drug Protein Interaction Databases

Adrian Schreyer, Alicia Higueruelo, Will Pitt.

Seminar Room, Sanger Building.

Wednesday 26 January 2011, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The Ghosts of PDBe Past, Present  and Yet to Come

Dr Gerard Kleywegt, PDB Europe, EBI, Hinxton.

Seminar Room, Sanger Building.

Wednesday 12 January 2011, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

i-SITE: An energetic approach to predict ligand-binding site on protein surface

Dr Mizuki Morita, Laboratory of Bioinformatics, National Institute of Biomedical Innovation (NIBIO), Japan.

Seminar Room, Sanger Building.

Monday 10 January 2011, 11:30-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The rational design of small-molecule Neuropilin-1 antagonists

Trevor Perrior, Research Director of Domainex.

Seminar Room, Sanger Building.

Wednesday 14 July 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Restraints on Protein Models from NMR Chemical Shifts

Rinaldo Wander Montalvao (Chemistry, Cambridge)..

Seminar Room, Sanger Building.

Wednesday 07 July 2010, 10:35-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Software for fragment linking and growing.

Nikolay Todorov (Molscape).

Seminar Room, Sanger Building.

Wednesday 07 July 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Using Biacore for fragment screening

Catherine McDonnell, GE Healthcare.

Seminar Room, Sanger Building.

Wednesday 30 June 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Off-site Targets: Predicting drug polypharmacology using ligand similarity ensembles.

Michael Keiser (UCSF).

Seminar Room, Sanger Building.

Wednesday 23 June 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Targetting Protein-Protein Interactions: Synergies between NCEs and New Antibodies.

Dr Alastair Lawson (UCB- Celltech).

Seminar Room, Sanger Building.

Wednesday 16 June 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fragment-based drug discovery using X-ray crystallography.

Dr Anne Cleasby (Astex).

Seminar Room, Sanger Building.

Wednesday 02 June 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Can machines understand the Scientific Literature?

Professor Peter Murray Rust (Unilever Centre, Chemistry, Cambridge).

Seminar Room, Sanger Building.

Wednesday 19 May 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY

Dr Ilona Nudelman, Weizmann Institute.

Seminar Room, Sanger Building.

Monday 10 May 2010, 11:15-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Engineering proteins for fragment screening

Speaker to be confirmed.

Seminar Room, Sanger Building.

Wednesday 17 March 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Surface Plasmon Resonance

Speaker to be confirmed.

Seminar Room, Sanger Building.

Wednesday 10 March 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

STING_DB

Dr Goran Neshi, Laboratorio de Biologia Computacional, Cidade Universitária "Zeferino Vaz" , Campinas, Brazil.

Seminar Room, Sanger Building.

Wednesday 24 February 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Drug-protein Databases: ZINC, Credo, CHEMBL

Will; Adrian.

Seminar Room, Sanger Building.

Wednesday 17 February 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fragments versus traditional screening . Off-target analysis

Speaker to be confirmed.

Seminar Room, Sanger Building.

Wednesday 10 February 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

ITC

Leo and Marko.

Seminar Room, Sanger Building.

Wednesday 03 February 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

X-ray single soaks or cocktails? Growing versus Linking. 

Round table (Tom and May to lead), Dave Huggins.

Seminar Room, Sanger Building.

Wednesday 27 January 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Targetting PPI

Alicia and Narcis Fernandez-Fuentes from the Leeds Institute of Molecular Medine (LIMM).

Seminar Room, Sanger Building.

Wednesday 20 January 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Recap of Experimental Fragment-based projects

May, Marko, Anja, Anna, Michal, Sachin, Marcio, Leo, Noha.

Seminar Room, Sanger Building.

Wednesday 13 January 2010, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Completely in vitro protein engineering automation

Prof Homme Hellinga, Duke University.

Lecture theatre, Sanger Building.

Monday 16 November 2009, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Molecular recognition - from single target to protein complexes

Dr Agata Kranjc Pietrucci from International School of Advanced Studies, Trieste, Italy.

Seminar Room, Sanger Building.

Thursday 15 October 2009, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

HIV-1 Reverse Transcriptase: Structure, Drug Resistance, and Drug Design

Professor Eddy Arnold, Rutgers University.

Lecture theatre, Sanger Building.

Thursday 11 June 2009, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The microseed matrix screening method for protein crystallisation

Dr May Marsh.

Seminar Room, Sanger Building.

Wednesday 03 June 2009, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Electrochemically-assisted protein crystallisation: Applications to biosensors

Professor Abel Moreno.

Seminar Room, Sanger Building.

Wednesday 01 April 2009, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Public domain medicinal chemistry data at the EBI and the use in drug discovery

Dr John Overington, Chemogenomics and ChEMBL Databases, European Bioinformatics Institute (EMBL-EBI).

Seminar Room, Sanger Building.

Wednesday 11 March 2009, 10:00-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The influence of electric and magnetic fields to increase the crystal quality of proteins

Professor Abel Moreno.

Seminar Room, Sanger Building.

Wednesday 04 March 2009, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The role of impurities in protein crystallisation: advantages and disadvantages

Professor Abel Moreno.

Seminar Room, Sanger Building.

Wednesday 11 February 2009, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein Crystal Growth in Gels and Capillary Tubes

Professor Abel Moreno.

Seminar Room, Sanger Building.

Wednesday 04 February 2009, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Conventional and non-conventional methods of protein crystal growth

Professor Abel Moreno.

Seminar Room, Sanger Building.

Wednesday 28 January 2009, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Recent adventures in protein folding and design

Professor Lynne Regan, Yale University.

Unilever Lecture Theatre, Department of Chemistry.

Monday 15 December 2008, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Leaving drinks for Sheena

Dr Sheena D'Arcy.

Panton Arms pub, Panton Street.

Friday 05 December 2008, 17:30-23:59

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

SPR - theory and practise

Dr Joe Maman.

Meeting Room A.

Thursday 04 December 2008, 13:00-14:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Biocore

Speaker to be confirmed.

Lecture Theatre, Department of Biochemistry, Hopkins Building (old building).

Wednesday 03 December 2008, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Expression systems for protein complexes

Dr Imre Berger, EMBL, Heidelberg.

Lecture Theatre, Department of Biochemistry, Hopkins Building (old building).

Wednesday 19 November 2008, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Pathway-based analysis of genome-wide siRNA screens

Dr. Miguel Camargo, Merck, Boston USA.

Seminar Room, Sanger Building.

Wednesday 12 November 2008, 10:15-11:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Party for Richard and Timo

All welcome!.

Seminar Room, Sanger Building.

Friday 24 October 2008, 15:00-16:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fragment-based Screening and It's Role in Ontario Cancer Institute

Prof Nickolay Chirgadze, Department of Pharmacology and Toxicology, University of Toronto.

Seminar Room, Sanger Building ?.

Sunday 12 October 2008, 11:15-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Molecular Puzzles: Learning About Function and Mechanism of Enzymes From their Structures

Dr. Alex Wlodawer, Macromolecular Crystallography Laboratory, National Cancer Institute Frederick.

Seminar Room, Sanger Building.

Friday 10 October 2008, 13:00-14:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Convergence of Molecular Epidemiology, Functional Biology and Host-pathogen Interactions: Zeroing on Potential Drug Targets for M. TUBERCULOSIS

Professor Seyed E. Hasnain, Vice-Chancellor University of Hyderabad.

Seminar Room, Sanger Building.

Wednesday 08 October 2008, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

test

Speaker to be confirmed.

Seminar Room, Sanger Building.

Thursday 14 August 2008, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Neurotrophic factors in Drosophila

Dr Alicia Hidalgo, University of Birmingham.

Seminar Room, Sanger Building.

Friday 18 July 2008, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Small hydrogen-bonded motifs in proteins and their significance for amyloid formation

James Milner-White, University of Glasgow.

Seminar Room, Sanger Building.

Thursday 26 June 2008, 11:30-12:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural chemistry in the pharmaceutical industry: view from a returned exile

Dr Nic Harmer, University of Exeter.

Meeting Room B, Sanger Building.

Monday 12 May 2008, 13:00-14:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

DNA site-specific recombination: Architecture of a recombinase

Professor Marshall Stark University of Glasgow.

Seminar Room, Sanger Building.

Wednesday 09 April 2008, 12:00-13:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Mechanisms of Transmembrane Transport: towards structures of membrane protein drug targets

Professor Robert Stroud, University of California, San Francisco.

Biochemistry Lecture Theatre, Sanger Building.

Monday 07 April 2008, 13:00-14:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Toll like receptors - Investigating innate immunity and infection

Dr Kathy Triantafilou, Infection and immunity Group, University of Sussex.

Seminar Room, Sanger Building.

Friday 28 March 2008, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

High intrinsic binding specificity mediates the interactions of a yeast SH3 domain

Dr. Elliott Stollar, Program in Molecular Structure and Function, Hospital for Sick Children, Toronto.

Seminar Room, Sanger Building.

Friday 14 March 2008, 12:00-13:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Expriences in Structure-based Discovery

Prof Rod Hubbard, Vernalis and University of York.

Seminar Room, Sanger Building.

Monday 03 March 2008, 09:00-10:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fragment based drug discovery - from crystal to clinic

Dr David Rees, Astex Therapeutics.

Seminar Room, Sanger Building.

Monday 03 December 2007, 09:00-10:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Paradoxical Features of Nicotinic Receptor

Professor Stuart Edelstein, University of Geneva.

Seminar Room, Sanger Building.

Wednesday 14 November 2007, 12:00-13:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

New protein purification columns and media from GE Healthcare

Penny Hamlyn, GE Healthcare.

Seminar Room, Sanger Building.

Thursday 08 November 2007, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

UCB Approaches to Drug Discovery, A Focus on 2 Cambridge projects

Dr Will Pitt, UCB Celltech.

Biochemistry Lecture Theatre, Sanger Building.

Monday 05 November 2007, 09:00-10:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural basis of fatty acid synthesis catalyzed by giant multienzyme complexes

Dr Nenad Ban, Professor of Structural Molecular Biology, ETH Zurich, Swiss Federal Institute of Technology.

Seminar Room, Sanger Building.

Friday 02 November 2007, 14:15-15:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The long and the short: virulence proteins from Staphylococcus and Streptococcus

Professor Ted Baker, Director, Centre for Molecular Biodiscovery.

Biochemistry Lecture Theatre, Sanger Building.

Friday 19 October 2007, 15:00-16:00