"Post-transcriptional regulation dictates T cell functionality in health and disease"

Add to your list(s) Download to your calendar using vCal

• Dr Fiamma Salerno; Sanquin Blood Supply Foundation, Amsterdam,The Netherlands
• Friday 10 November 2017, 13:00-14:00
• Babraham - The Cambridge Building; Kings Hedges Room.

If you have a question about this talk, please contact Bobbie Claxton.

If you would like to attend this seminar, please contact us to arrange site access

Memory T cells are critical to protect us from recurring infections. Their instantaneous reactivity to pathogens is empowered by persistent expression of cytokine mRNA. How aberrant cytokine production of this pre-formed mRNA is prevented in the absence of infection remains, however, unresolved. Here, I will discuss how post-transcriptional regulation through AU-rich elements is key to block chronic production of cytokines in memory T cells. Importantly, for swift recall responses to infection, this translational block must be rapidly relieved and pre-formed cytokine mRNA serves as ready-to-be-translated template. This switch is achieved by loss of the suppressive capacity of the RNA -binding protein ZFP36L2 . Finally, I propose that altering the post-transcriptional regulation of IFN production can be exploited to improve the efficacy of T cell therapy for cancer treatment.

This talk is part of the Babraham Seminar series.

This talk is included in these lists:

• Babraham - The Cambridge Building; Kings Hedges Room
• Babraham Seminar
• Graduate-Seminars
• se393's list

Note that ex-directory lists are not shown.