"Regulatory feedback from nascent RNA to chromatin"

Add to your list(s) Download to your calendar using vCal

• Dr Richard Jenner; UCL Cancer Institute, University College London
• Wednesday 15 March 2017, 13:00-14:00
• Babraham - The Brian Heap Seminar Room.

If you have a question about this talk, please contact Bobbie Claxton.

Hosted By: Dr Martin Turner

Transcription and chromatin function are regulated by proteins that bind DNA , nucleosomes or RNA polymerase II, with specific non-coding RNAs (ncRNAs) functioning to modulate their recruitment or activity. By contrast, nascent pre-mRNA has primarily been considered a passive player in these processes. Focusing on polycomb repressive complex 2 (PRC2), I will present data from our lab that suggest that nascent pre-mRNA in fact plays an active role in regulating chromatin state. I will also discuss recent work revealing the transcriptional mechanisms underlying lineage specification of CD4 + T cells and how disregulation of these mechanisms is associated with increased risk of auto-inflammatory disease.

This talk is part of the Babraham Seminar series.

This talk is included in these lists:

• Babraham - The Brian Heap Seminar Room
• Babraham Seminar
• Graduate-Seminars
• se393's list

Note that ex-directory lists are not shown.