|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
“Creating New In-Roads for Cancer-Specific T Cells”
If you have a question about this talk, please contact Matt Humphries.
Hosted By: Rahul Roychoudhuri
One limitation to successful cancer immunotherapy is the immunosuppressive effects of Tregs which are highly enriched in many tumours. This talk will focus on the impact of these cells in the context of human colorectal cancer (CRC) and in mouse models of cancer. In the case of CRC , Tregs are associated with disease progression and a paucity of T cell responses to tumour-associated antigens. Modulation of Treg numbers restores these immune responses, possibly leading to control of disease progression. In the case of mouse models, the talk will focus on the impact of Treg on the tumour vasculature. Modulating Treg numbers/activity results in alterations to the vasculature that serve to increase the frequency of tumour-infiltrating T cells and improve control of tumour growth. These findings could inform future therapeutic approaches to increase access of effector cells to the tumour microenvironment.
This talk is part of the Babraham Seminar series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsThe Eastern Counties Branch of The Welding Institute Dr. Mira Phailbus talks about the education system in Pakistan Semiconductor Physics
Other talksFree-Form Gesture Passwords: Security, Memorability, Usability Jeff Tabor (Rice University)- Title to be confirmed Longevity and anticancer mechanisms in the naked mole rat Prof Robyn Slattery: The Songlines between Scientific and Social Silos: A nomadic approach to Immunology teaching, learning and research Cambridge-Lausanne Workshop 2018 - Day 1 Deep Learning: Artificial Intelligence Meets Human Intelligence