|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
"Group 2 Innate Lymphoid cells at the interface between innate and adaptive immunity"
If you have a question about this talk, please contact Matt Humphries.
Hosted By: Dr Rahul Roychoudhuri
Group 2 innate lymphoid cells (ILC2) are a newly discovered subset of lymphocytes that are known to be prolific producers of inflammatory cytokines. We have found that ILC2 are tissue resident cells in the airways, and can be rapidly activated by epithelial-derived stress factors such as interleukin (IL)-33 to promote acute allergic (Type-2) lung inflammation. Moreover, we have also shown that ILC2 , through production of IL-13, can influence the migration of lung dendritic cells (DC) to the draining lymph nodes. It is there that DCs encounter and subsequently activate naïve CD4 T cells, which become polarized to a T helper 2 (TH2) cell phenotype. Subsequently, lung ILC2s also stimulate lung DCs to produce CCL17 , which attracts the memory TH2 cells into the lungs. Thus, ILC2 are an important regulator of tissue-specific innate and adaptive type-2 inflammation, and provide a critical link between the epithelium and innate and adaptive immune system.
This talk is part of the Babraham Seminar series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsCambridge Centre for Climate Change Mitigation Research Seminar Series IV EURASIAN RESEARCH FORUM Film screening - Salaam Bombay!
Other talksScientific habits circa 1900 The 5th Annual Sir John Walker Lecture, "The mitochondrial calcium uniporter: molecular identity and physiological role" Asclepiadaceae Exploring psychotic experiences in ‘non-need for care’ populations: Findings from the UNIQUE study Research Data Management: Workshop (For GSLS PhD students) Merck, Sharp & Dohme Lecture