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"RhoGEFs as signaling platforms of chemotactic GPCRs"

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  • UserJosé Vázquez-Prado; Department of Pharmacology, The Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN) Mexico
  • ClockThursday 09 March 2017, 13:00-14:00
  • HouseBabraham - The Brian Heap Seminar Room.

If you have a question about this talk, please contact Bobbie Claxton.

Hosted By: Dr Heidi Welch

Cancer cells and stroma cells in tumors secrete chemotactic agonists that exacerbate invasive behavior, promote tumor-induced angiogenesis, and recruit protumoral bone marrow-derived cells. In response to shallow gradients of chemotactic stimuli recognized by G protein-coupled receptors (GPCRs), Gbg-dependent effectors such as Phosphoinositide-3-kinases and Rac guanine nucleotide exchange factors, such as P-Rex1, contribute to the activation of Rho GTPases and their cytoskeletal-remodeling effectors. P-Rex1, as many other Rho guanine nucleotide exchange factors coexpressed in protumoral cells, is a multidomain protein that interacts with multiple regulators and upstream signaling partners. The role of P-Rex1 as a signaling platform of chemotactic GPC Rs will be discussed based on its interactions with GPC Rs, Gbg and the serine/threonine kinases mTOR and PKA . Overall, the proven relevance of multiple chemokines in oncogenic settings has pointed to RhoGEFs as potential pharmacologic targets in cancer research.

This talk is part of the Babraham Seminar series.

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