University of Cambridge > Talks.cam > Meeting the Challenge of Healthy Ageing in the 21st Century > Synthesis and bioevaluation of Resveralogues: a multidimensional approach to anti-degeneratives

Synthesis and bioevaluation of Resveralogues: a multidimensional approach to anti-degeneratives

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There is growing evidence that many of the deleterious processes of ageing may be modulatable by simple chemical compounds. A wide variety of polyphenolic natural products, most notably resveratrol, have been identified as potential leads for anti-degenerative therapeutics. The complexity of activities of these compounds led us to develop simple, robust syntheses to produce a designed panel of compounds, termed “Resveralogues”, to be used in the first rational, multidimensional SAR study of stilbenes. We have evaluated this panel to determine the specific structural features that underpin differential bioactivities. Available compounds, synthetic methods and SAR will be presented.

This talk is part of the Meeting the Challenge of Healthy Ageing in the 21st Century series.

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