University of Cambridge > Talks.cam > Three-dimensional cell culture: Innovations in tissue scaffolds and biomimetic systems > Intrinsic and extrinsic determinants of pancreatic cancer stem cells

Intrinsic and extrinsic determinants of pancreatic cancer stem cells

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  • UserProfessor Christopher Heeschen, Queen Mary University of London, London, United Kingdom
  • ClockWednesday 08 February 2017, 09:30-10:00
  • HouseOnline.

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Apart from functioning as a mechanical barrier and providing structural support for tumour growth and development, the tumour microenvironement (TME) mostly constitutes a dynamic heterogeneous cell compartment that provides an important niche for the embedded cancer (stem) cells. While it has been shown conclusively that cancer stem cells (CSC) bear cell-intrinsic stemness features, they are also a product of their relationship with the TME , promoting their aggressiveness including metastasis and drug resistance. Therefore, we are developing ex vivo 3D models that faithfully resemble the in vivo tumour biology and allow us to study CSC in a comprehensive TME .

This talk is part of the Three-dimensional cell culture: Innovations in tissue scaffolds and biomimetic systems series.

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