University of Cambridge > Talks.cam > Three-dimensional cell culture: Innovations in tissue scaffolds and biomimetic systems > Gene Activated Matrices for Bone Regeneration

Gene Activated Matrices for Bone Regeneration

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  • UserProfessor Aliasger K. Salem, College of Pharmacy, University of Iowa, 115 S. Grand Avenue, Lowa City, United States
  • ClockWednesday 08 February 2017, 14:30-15:00
  • HouseOnline.

If you have a question about this talk, please contact Ilana Spilka.

Gene therapy using non-viral vectors that are safe and efficient in transfecting target cells is an effective approach to overcome the shortcomings of protein delivery of growth factors. The objective of our study was to develop and test a non-viral gene delivery system for bone regeneration utilizing a collagen scaffold to deliver polyethylenimine (PEI)-plasmid DNA (pDNA) [encoding platelet derived growth factor-B (PDGF-B)] complexes. In vivo studies showed significantly higher new bone volume/total volume (BV/TV) % in calvarial defects treated with the complex-activated scaffolds following 4 weeks of implantation (14-and 44-fold higher) when compared to empty defects or empty scaffolds, respectively.

This talk is part of the Three-dimensional cell culture: Innovations in tissue scaffolds and biomimetic systems series.

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