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Gut microbiota affects skin wound healing of mice by activating immune-endocrine-brain axis elements

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  • UserDr. Theofilos Poutahidis, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • ClockTuesday 31 January 2017, 09:00-09:30
  • HouseOnline.

If you have a question about this talk, please contact Ilana Spilka.

Using mice we have shown that edible Lactobacillus reuteri accelerates skin wound healing. The wounds of animals consuming either live or lysed probiotic bacteria healed in half the time required for matched control animals. Experiments involving genetically engineered mice and cell transfer methodologies suggest that this phenomenon is mediated by regulatory T cells and the hormone oxytocin, which is consistently upregulated after the consumption of L. reuteri. This result showcases that the gut microbiome and host animal interact via immune-endocrine-brain signaling networks. Exploiting this interaction opens a new window for preventing and therapeutic strategies based on edible bacteria products.

This talk is part of the Innovations in wound healing and wound management series.

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