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The transcriptional battle between phage and host in the Pseudomonas phage infected cell

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  • UserMr Bob G Blasdel, KU Leuven, Leuven, Belgium
  • ClockWednesday 18 January 2017, 08:30-09:00
  • HouseOnline.

If you have a question about this talk, please contact Ilana Spilka.

Detailed knowledge of phage lifecycles, have been limited to few model bacteriophages mostly infecting Escherichia coli as well as the results of increasingly antiquated methods. However, next-generation techniques now make it possible to explore how phage affect host transcription and metabolism, now re-sparked by modern therapeutic and biotechnological potential, as well as to ask deeper more comprehensive questions. By performing RNA -Seq on synchronously infected cells we are able to compare host transcript data for early, middle and late transcription with six fundamentally different lytic phages: N4likevirus, Phikzlikevirus, Yualikevirus, Pbunalikevirus, Phikmvlikevirus, and novel F7-like viruses infecting P. aeruginosa PAO1 .

This talk is part of the Bacteriophage 2017 series.

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