The phage T4 DNA and protein packaging machine – Old, New, Widely true, useful too

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• Professor Lindsay W. Black, Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, USA
• Tuesday 17 January 2017, 14:30-15:00
• Online.

If you have a question about this talk, please contact Ilana Spilka.

Viral genome packaging into capsids is powered by ATP driven high-force-generating motor proteins. In vitro the phage T4TerL alone packages any linear DNA into portal containing proheads by “crunching” it transiently from B- to A-form. But In vivo we show that a twin ring form of T4 TerS is required to gauge DNA synthesis adequate for packaging by “synapsing” two homologous pac sites. The Protein And Nucleic Acid Targeting System Using T4 Phage (PANTSUP) viral nanocontainer can be used for highly efficient and specific transfer of active proteins and corrected sequence DNA into genetically-deficient cell lines. Refs:PMID:25728298

This talk is part of the Bacteriophage 2017 series.

This talk is included in these lists:

• Bacteriophage 2017
• Cambridge Infectious Diseases
• Online

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