Modelling cardiovascular and metabolic disease using transgenic zebrafish

Add to your list(s) Download to your calendar using vCal

• Dr Marcel den Hoed, Department of Medical Sciences, Molecular Epidemiology and SciLifeLab, Uppsala University.
• Wednesday 14 December 2016, 12:30-13:30
• Meeting rooms, Level 4 Institute of Metabolic Sciences, Addenbrooke’s Treatment Centre (ATC).

If you have a question about this talk, please contact Paul.Browne.

Genome-wide association studies identified hundreds of loci that are associated with cardiometabolic diseases and risk factors. For most loci the causal genes remain unknown. My group developed experimental pipelines that facilitate image-based genetic screens in zebrafish larvae by using: 1) the zebrafish’ well-annotated genome; 2) CRISPR -Cas9 based mutagenesis; 3) fluorescent transgenes and dyes; 4) automated positioning and imaging technologies; 5) custom-written image quantification pipelines. Results from dietary, drug and genetic screens confirm that zebrafish larvae represent an opportunity to identify causal genes for cardiometabolic diseases and risk factors, and increase our understanding of disease aetiology.

This talk is part of the MRC Epidemiology and CEDAR Seminars series.

This talk is included in these lists:

• Annual Food Agenda
• BHRU Annual Lecture 2015
• BHRU Annual Lecture 2016
• Cambridge Cardiovascular Seminar Series
• Cambridge Global Food Security
• Cardiovascular Epidemiology Unit Special Seminars
• Department of Public Health and Primary Care
• MRC Epidemiology and CEDAR Seminars
• Meeting rooms, Level 4 Institute of Metabolic Sciences, Addenbrooke’s Treatment Centre (ATC)
• Primary Care
• PublicHealth@Cambridge
• Talks related to sustainability and the environment
• history
• my_list
• primary care

Note that ex-directory lists are not shown.