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Integrative Structural Biology

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If you have a question about this talk, please contact Claus Bendtsen.

Integrative structural biology combines data obtained by progressive high-resolution methods such as single-crystal X-ray diffraction, small angle X-ray scattering, NMR , HDX-MS, and Cryo-Electron microscopy to build enriched, dynamic, models of macromolecules and the multi-component complexes they form. Three talks are presented which together illustrate the use of integrative structural biology techniques to build our understanding of the mechanistic biology and the mode of action of specific inhibitors for diverse drug targets of interest.

1) BRD4 Bivalent Inhibitors: two BD or not two BD? Derek Ogg, AstraZeneca

2) An Integrative Structural Biology Study of FGFR1 . Geoff Holdgate, AstraZeneca

3) Architecture of a PIKK - TOR structure revealed by cryo-EM. Domagoj Baretić, LMB , Cambridge

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