University of Cambridge > Talks.cam > Cambridge Cardiovascular Seminar Series > CANCELLED: Effects of genetic variation on cellular pluripotency and its implications for modelling functional effects of human disease alleles in iPSCs

CANCELLED: Effects of genetic variation on cellular pluripotency and its implications for modelling functional effects of human disease alleles in iPSCs

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PLEASE NOTE : THIS TALK IS CANCELLED DUE TO ILLNESS

Induced pluripotent stem cells (iPSCs) are a powerful model system for studying the cellular basis of human health and disease. The Human Induced Pluripotent Stem Cell Initiative (www.hipsci.org) is generating iPSC lines from 500 healthy individuals and 500 individuals with rare disorders, which will be made available to the research community. The lines are extensively profiled for diverse cellular phenotypes to elucidate the biological properties and genetic basis of pluripotency. I will describe the HipSci resource and initial analysis of about 600 iPSC lines from approximately 200 healthy donors, which has enabled a comprehensive assessment of variation and heterogeneity in these lines. Preliminary findings suggest that genetic effects on molecular traits, such as gene expression, can be robustly identified in iPSCs, often explaining a substantially larger proportion of the variance than other technical and biological factors. Rapidly accumulating data within the HipSci resource allows us to study how gene expression variability affects the epigenome, protein abundances, and imaging-based phenotypes of whole cells, and how findings from iPSCs relate to adult tissues and disease association studies.

This talk is part of the Cambridge Cardiovascular Seminar Series series.

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