University of Cambridge > Talks.cam > Cambridge Cardiovascular Seminar Series > CVD Forum: Transcriptional variation in human induced pluripotent stem cells (iPSCs) and their derivatives

CVD Forum: Transcriptional variation in human induced pluripotent stem cells (iPSCs) and their derivatives

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About the speaker: Daniel earned his PhD in evolutionary genetics from Edinburgh University in 2006 under the supervision of Dr Peter Keightley. His graduate research used computational methods to study variation in the mutation rate and natural selection in noncoding DNA . From 2006 to 2008 he pursued a postdoc with Dr Jacek Majewski in McGill University and Genome Quebec Genome Centre, where he worked on the evolution of transcriptional regulation in primates, and the role of alternative splicing in embryonic development. From 2008 until 2011 he worked on population genetic variation in gene expression and regulation with Dr Jonathan Pritchard at the University of Chicago.

In July 2011 Daniel started as a Career Development Fellowship Group Leader at the Wellcome Trust Sanger Institute. The long-term goal of the group is to understand how changes in gene regulation play a role in disease susceptibility and human evolution. His research combines statistical genetics and comparative genomics with high-throughput experimental techniques, such as ChIP-seq and DNaseI-seq, in human cells to address these questions. The group uses naturally occurring human genetic variation as a model system to test hypotheses about gene regulation. The team is also interested in developing evolutionary models of gene regulation to understand how changes at the molecular level drive gene expression divergence between species.

This talk is part of the Cambridge Cardiovascular Seminar Series series.

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