COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring. |
University of Cambridge > Talks.cam > Plant Sciences Talks > Small RNAs as morphogen-like signals in the patterning of leaves
Small RNAs as morphogen-like signals in the patterning of leavesAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact up220. Establishment of adaxial-abaxial (top/bottom) polarity is essential for the flattened outgrowth and patterning of leaves, and forms a key innovation in the evolution of land plants. We have shown that this polar axis is established through a cascade of opposing small RNAs in which miR390 triggers the biogenesis of a second class of small RNAs, the tasiR-ARFs, which in turn regulate the accumulation of miR166. Importantly, we showed that tasiR-ARF traffics from cell to cell. Movement of tasiR-ARF creates a gradient of accumulation across the leaf that dissipates towards the abaxial/bottom side. This gradient is interpreted into a sharp on-off domain of expression of the target and abaxial cell fate determinant ARF3 . Likewise, miR166 traffics from its site of biogenesis in the bottom epidermal layer to restrict expression of adaxial determinants, the HD-ZIPIII transcription factors, to the upper domain of the leaf. Mathematical modelling predicts that the opposing small RNA gradients generated through mobility are uniquely suited to create sharply defined and robust patterning boundaries. This model is supported by our recent observations, which will be presented. Our observations indicate that leaves are partitioned into top and bottom domains via a novel patterning mechanism involving opposing gradients of small RNAs that act as mobile morphogen-like instructive signals. This talk is part of the Plant Sciences Talks series. This talk is included in these lists:Note that ex-directory lists are not shown. |
Other listsCentre for Smart Infrastructure & Construction Seminars J M Keynes Fellowship Fund Lectures Life Science Active Materials British Antarctic Survey CU Explorer's SocietyOther talksDirect measurements of dynamic granular compaction at the mesoscale using synchrotron X-ray radiography Grammar Variational Autoencoder Public innovation: can innovation methods help solve social challenges? Speak white, speak black, speak American Microsporidia: diverse, opportunistic and pervasive pathogens Single Cell Seminars (November) A transmissible RNA pathway in honeybees The role of the oculomotor system in visual attention and visual short-term memory Graph Legendrians and SL2 local systems 'The Japanese Mingei Movement and the art of Katazome' Exploring the Galaxy's alpha-element abundances and globular cluster populations with hydrodynamic simulations |