University of Cambridge > Talks.cam > Annual Meeting of the Cambridge Cell Cycle Club > The impact of cohesin on the regulation of gene expression and the organization of chromatin.

The impact of cohesin on the regulation of gene expression and the organization of chromatin.

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  • UserMatthias Merkenschlager Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
  • ClockTuesday 23 April 2013, 17:00-17:45
  • HouseREGISTRATION REQUIRED: http://bit.ly/15Ftmpi.

If you have a question about this talk, please contact Viji M. Draviam.

Cohesin-mediated sister chromatid cohesion is essential for chromosome segregation and post-replicative DNA repair. Growing evidence from human genetics and model organisms links cohesin to the formation of long-range chromosomal interactions and to the regulation of gene expression in association with CTCF , mediator, or tissue-specific transcription factors. We have taken genetic approaches to determine the impact of cohesin on developmentally regulated gene expression and the organization of chromatin in non-dividing mammalian cells. Since gene dosage reductions in the cohesin loading factor Nipbl are the leading cause of Cornelia de Lange syndrome, we have also investigated the transcriptional and post-transcriptional regulation of Nipbl expression.

This talk is part of the Annual Meeting of the Cambridge Cell Cycle Club series.

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