Centrality clubs and concepts of the core: decoding the communicative organisation of brain networks

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• Emma Towlson, Department of Physics (Cavendish Laboratory), University of Cambridge
• Tuesday 09 October 2012, 11:00-12:00
• BCNI seminar room, Sir William Hardy Building, Downing Site.

If you have a question about this talk, please contact Mikail Rubinov.

There has been increasing interest in topological analysis of brain networks as complex systems, often on the basis of neuroimaging data which typically represent the large-scale organisation of nervous systems. We use graph theory to identify and investigate the so-called ‘rich-club’ phenomenon, characterised by the presence of a densely interconnected set of hub nodes, of the neuronal connectome of the nematode C. elegans. We discuss the globally integrative nature of the rich club and the trade-off between high wiring cost and behavioural value. Structural data on the human brain has already found evidence of such a rich-club, which we identify within functional networks extracted from rest state fMRI data. We go on to discuss an extension to a generalised family of centrality clubs and suggest a mechanism by which to quantify the effectiveness of antipsychotic medication at combatting schizophrenia.

This talk is part of the Brain Mapping Unit Networks Meeting and the Cambridge Connectome Consortium series.

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• BCNI seminar room, Sir William Hardy Building, Downing Site
• Brain Mapping Unit Networks Meeting and the Cambridge Connectome Consortium
• Department of Psychiatry talks stream

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