Ana Patricia Ramos-Forming an Eye: from cell behaviour to tissue shape changes;

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• Kumud Saini, Robinson Lab, Sainsbury Laboratory & Ana Patricia Ramos, IGC, Portugal
• Monday 09 June 2025, 14:30-15:30
• Online.

If you have a question about this talk, please contact Jia CHEN.

Ana Patricia Ramos

Title:Forming an Eye: from cell behaviour to tissue shape changes

Abstract: Building an organ is a multistep process in which correct morphogenesis arises from feedback loops between genetic regulation and mechanical forces. A key morphogenetic event is the emergence of tissue curvature, which is essential for various developmental processes, such as gastrulation, and shapes multiple organs, including the heart and neural tube.

Curvature can develop alongside other cellular and tissue rearrangements. In many of these complex contexts, the biomechanical interactions driving curvature remain unclear, as the contributions of individual rearrangements and their interplay are difficult to disentangle.

To address this, we investigated the morphogenesis of the vertebrate optic cup, a highly curved structure that forms from a flat bilayered optic vesicle. Using zebrafish as a model system, where cell and tissue dynamics can be studied in native 4D conditions, we combined in vivo experiments, 4D segmentation and analysis, and theoretical modeling. This interdisciplinary approach allowed us to identify key players driving the emergence of optic cup curvature.

This talk is part of the Morphogenesis Seminar Series series.

This talk is included in these lists:

• Graduate-Seminars
• Morphogenesis Seminar Series
• Online

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