Cancer Diagnostics and Therapy with DNA Aptamer Nanotechnology

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• Prof. Maxim Berezovski, University of Ottawa, Canada
• Thursday 17 April 2025, 12:00-13:00
• LT2, Department of Chemical Engineering and Biotechnology, Philippa Fawcett Drive.

If you have a question about this talk, please contact Alexei Lapkin.

This presentation explores the innovative application of DNA aptamer nanotechnology in cancer diagnostics and therapy. Cancer-specific DNA aptamers have been developed to address critical challenges in tumor localization, margin assessment, circulating tumor cell detection, and adjuvant treatment. Two novel aptamer-based technologies are highlighted: Aptamer-assisted Fluorescence-Guided Surgery (AptaFGS) and Aptamer-guided MagnetoDynamic cell disruption (AptaMD). In AptaFGS, a tumor-specific aptamer spray is formulated for glioblastoma neurosurgery. This approach eliminates the need for systemic drug administration, offering a simple, rapid procedure that enables surgeons to distinguish tumor tissue from healthy tissue in real-time. AptaMD uses aptamer-modified gold-coated magnetic nanoparticles exposed to an alternating magnetic field for selectively destroying cancer cells. This technique achieves tumor cell disruption without inducing heat damage, preserving the surrounding healthy tissue. These advancements demonstrate the potential of synthetic affinity ligands (aptamers) to improve intraoperative tumor imaging and postoperative cancer cell eradication, paving the way for more precise and effective cancer treatments.

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• LT2, Department of Chemical Engineering and Biotechnology, Philippa Fawcett Drive

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