Chemo-mechanical signal in embryo development

Add to your list(s) Download to your calendar using vCal

• Roberto Mayor
• Monday 18 November 2024, 14:30-15:30
• In person at Physiology Lecture Theather, and online.

If you have a question about this talk, please contact Jia CHEN.

Sir J. Gurdon has claimed that embryonic induction “is probably the single most important mechanism in vertebrate development, leading to differences between cells and the organization of cells into tissues and organs” (1987). Although embryonic induction was discovered over a hundred years ago (Spemann and Mangold, 1924), its molecular basis has only been elucidated in the last three decades with the identification of many inducers. However, this remarkable achievement—identifying the inductive molecules—addresses only half of the problem. Crucially, embryonic induction also requires tissues to be responsive to the inductive signals they receive (a concept known as embryonic competence); a topic that has been widely neglected. Thus far, researchers have focused on the molecules that may control competence, while the role of mechanics as a potential regulator of embryonic competence has remained unexplored. We demonstrated that the neural crest inductive signal (Wnt) is modulated by the mechanotransducer Yes Associated Protein (YAP), illustrating how mechanical and biochemical cues interplay to control embryonic competence. To demonstrate the universality of our findings, we showed that the same mechanism operates in human-induced neural crest cells, in addition to Xenopus embryos.

Join the Zoom with the link: https://cam-ac-uk.zoom.us/j/87503254733 Meeting ID: 875 0325 4733

This talk is part of the Morphogenesis Seminar Series series.

This talk is included in these lists:

• Graduate-Seminars
• In person at Physiology Lecture Theather, and online
• Morphogenesis Seminar Series

Note that ex-directory lists are not shown.