Bioengineering neural organoid morphogenesis

Add to your list(s) Download to your calendar using vCal

• Adrian Ranga
• Monday 11 November 2024, 14:30-15:30
• Online.

If you have a question about this talk, please contact Jia CHEN.

Tissues and organs are sculpted by mechanical forces during embryonic development. Organoids provide remarkable in-vitro models to understand how forces lead to developmental complexity by allowing to deconvolve the interactions between differentiation, patterning, growth and morphogenesis. However it has been challenging to reproduce the range, scale and temporal tissue cytoarchitecture in-vitro. In this talk I will discuss our ongoing efforts in developing customized actuation devices and magnetic nanoparticle-based approaches which allow us to spatiotemporally control and manipulate mechanical forces, and how we use these technologies to study force-mediated neural patterning and morphogenesis. I will also discuss how we have used a newer model of geometrically constrained neural tube morphogenesis to uncover a novel mechanism underlying human neural tube closure. Our work with organoid-based models of neural tube patterning and morphogenesis suggests that the way forward towards engineering reproducible and scalable patterned tissue constructs and understanding mechanisms of neural morphogenesis and may involve harnessing cells’ inherent capacities for self-organization by providing geometrically and mechanically active microenvironments.

Join the Zoom with the link: https://cam-ac-uk.zoom.us/j/87503254733 Meeting ID: 875 0325 4733

This talk is part of the Morphogenesis Seminar Series series.

This talk is included in these lists:

• Graduate-Seminars
• Morphogenesis Seminar Series
• Online

Note that ex-directory lists are not shown.