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How do autophagosomes form and grow?

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Autophagy is vital for maintaining cellular homeostasis through the degradation of cellular components via the formation of double-membraned autophagosomes. However, the origin and growth of the autophagosome membrane remain elusive. In this talk, I will examine how the lipid trafficking ATG9A -ATG2A complex sits at the heart of autophagosome formation, and the impact of newly characterized protein complexes on autophagy and mitophagy.

Alex completed his PhD at KU Leuven under Patrizia Agostinis, supported by an IWT scholarship, working on how the ER stress kinase PERK affects membrane contact sites. He then joined Sharon Tooze’s lab at the Francis Crick Institute as an EMBO fellow, investigating the lipid scramblase ATG9A ’s role in autophagosome biogenesis and characterizing the lipid trafficking ATG9A -ATG2A protein complex. He is currently researching Rab1’s role in autophagy at the MRC LMB with Sean Munro.

This talk is part of the Babraham Seminar series.

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