University of Cambridge > > MRC Epidemiology and CEDAR Seminars > Seminar - Diabetes No More: lessons from the DiRECT trial and beyond - Professor Mike Lean

Seminar - Diabetes No More: lessons from the DiRECT trial and beyond - Professor Mike Lean

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If you have a question about this talk, please contact Paul Browne.

This hybrid seminar will be held in the meeting rooms, Level 4, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ , and online.

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About this talk Three RCT trials, conducted entirely in primary care using low-calorie formula diets for 8-12 weeks, have reported remissions for 40-60% of participants including South Asians, and 70-80% with weight loss >10kg, well maintained at 2 years. Hypertension and NAFLD , commonly accompanying T2D , normalized for ~30%. Remission was accompanied by normalization of ectopic fat in liver and pancreas, and insulin production capacity. With fewer serious adverse events, total medical care costs fell and cost-effectiveness analysis projected people to live longer, feel better and cost less. Remissions are strongly driven by weight loss, but new methods are needed to support longer maintenance.

This talk is part of the MRC Epidemiology and CEDAR Seminars series.

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