Seminar - Diabetes No More: lessons from the DiRECT trial and beyond - Professor Mike Lean

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• Professor Mike Lean, University of Glasgow
• Monday 20 February 2023, 13:00-14:00
• MRL meeting rooms 1 & 2, Level 4 Institute of Metabolic Sciences, Addenbrooke’s Treatment Centre (ATC) .

If you have a question about this talk, please contact Paul Browne.

This hybrid seminar will be held in the meeting rooms, Level 4, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ , and online.

Free registration to attend this seminar in person at:

https://www.eventbrite.com/e/diabetes-no-more-lessons-from-the-direct-trial-and-beyond-prof-mike-lean-tickets-536094692657

Free registration to join this seminar online at:

https://mrc-epid.zoom.us/meeting/register/tJIrduqsrD0tH9FccP1uJ-Rzmk1bRy7JyCl8

After registering, you will receive a confirmation email containing information about joining the meeting.

About this talk Three RCT trials, conducted entirely in primary care using low-calorie formula diets for 8-12 weeks, have reported remissions for 40-60% of participants including South Asians, and 70-80% with weight loss >10kg, well maintained at 2 years. Hypertension and NAFLD , commonly accompanying T2D , normalized for ~30%. Remission was accompanied by normalization of ectopic fat in liver and pancreas, and insulin production capacity. With fewer serious adverse events, total medical care costs fell and cost-effectiveness analysis projected people to live longer, feel better and cost less. Remissions are strongly driven by weight loss, but new methods are needed to support longer maintenance.

This talk is part of the MRC Epidemiology and CEDAR Seminars series.

This talk is included in these lists:

• Annual Food Agenda
• BHRU Annual Lecture 2015
• BHRU Annual Lecture 2016
• Cambridge Global Food Security
• Cardiovascular Epidemiology Unit Special Seminars
• Department of Public Health and Primary Care
• MRC Epidemiology and CEDAR Seminars
• MRL meeting rooms 1 & 2, Level 4 Institute of Metabolic Sciences, Addenbrooke’s Treatment Centre (ATC)
• Primary Care
• PublicHealth@Cambridge
• Talks related to sustainability and the environment
• history
• primary care

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