University of Cambridge > > Morphogenesis Seminar Series > How tissues orchestrate growth and morphogenesis – lessons from the vertebrate retina 

How tissues orchestrate growth and morphogenesis – lessons from the vertebrate retina 

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  • User Mauricio Rocha Martins (Instituto Gulbenkian Ciência (IGC), Oeiras, Portugal)
  • ClockMonday 17 October 2022, 14:30-15:30
  • HouseOnline.

If you have a question about this talk, please contact Elena Scarpa.

Most developing tissues acquire functional architecture as they still undergo significant growth. How differentiating and proliferating cells cooperate in crowded yet dynamic tissue environments in order to prevent spatial interference remains, however, largely unclear. In this seminar, I will introduce how we use the developing retina of zebrafish and human organoids to probe cell movements important for tissue growth and organization, as well as their coordination in space and time. I will present how quantitative imaging approaches revealed an unknown bidirectional migration phenomenon of one of the most studied retinal neurons, photoreceptors. Interestingly, this bidirectional migration occurs at peak proliferation stages and culminates in a transient relocation of the entire cell population away from the proliferative zone. We performed a comprehensive analysis of the molecular motors driving photoreceptor movements in different directions, and then exploited these mechanistic insights to determine the relevance of their movements to overall tissue morphogenesis. We found that photoreceptor movements are not directly needed for their correct lamination. However, blockage of photoreceptor migration congests the mitotic zone of the tissue causing intense progenitor delamination followed by secondary tissue disorganization. Our findings highlight that neuronal migration can play an important role in coordinating growth and morphogenesis by preventing spatial competition.

This talk is part of the Morphogenesis Seminar Series series.

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