University of Cambridge > > Morphogenesis Seminar Series > Computational Models of the Development of the Central Nervous System

Computational Models of the Development of the Central Nervous System

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  • UserDagmar Iber, ETH Zurich (Computational Biology)
  • ClockMonday 07 November 2022, 14:30-15:30
  • HouseOnline.

If you have a question about this talk, please contact Elena Scarpa.

The central nervous system develops from the neural plate, which folds into the neural tube. Subsequently, morphogen gradients define distinct neural progenitor domains along the dorsal-ventral axis, which give rise to the central nervous system. In my talk, I will present recent work from the group that addressed the folding mechanism of the neural tube [1], and that showed that the gradient-based patterning is much more precise than previously thought [2]. With the help of cell-based modelling, we further found that high patterning precision requires small cell diameters, pointing to the long-elusive evolutionary driving force behind the emergence of pseudostratified epithelia [3,4]. Finally, I will discuss the biophysical constraints that define the complex shape of cells in pseudostratified epithelia [5-8], and present our recently developed 3D simulation framework for the data-driven simulation of epithelial cell dynamics.

This talk is part of the Morphogenesis Seminar Series series.

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